Category Archives: CAM – Complementary Alternative Medicine

Exploiting a vulnerability in some forms of cancer: the Warburg Effect revisited


This paper builds on work done in the 1980s by moi (Dr. Anthony G. Payne) which capitalized on the Warburg Effect in some forms of cancer.


EXCERPT FROM MY FELLOWSHIP APPLICATION TO THE AMERICAN ACADEMY IN BERLIN (Submitted during the fall of 2019 for the 2020 award year):

In looking through the many completed Fellowship projects by American Academy of Berlin alumni as well as their biographical profiles, I quickly realized that both my proposal focus and background differs significantly from theirs. To quote myself, “I am the unconventional conventioneer”.

In keeping with my being a seeker of viable alternatives, the research I propose doing concerns maverick souls who exploited a metabolic defect that characterizes about 80% of the over 200 forms of cancer by throwing a monkey wrench in their inner  cellular works which culminated in tumor die-off in many of their patients. This defect, known as “the Warburg effect”, requires a little mental time travel:

Around 1923 German biochemist Otto Warburg, PhD, MD discovered that cancer cells use a lot of glucose and little or no oxygen to thrive (A process known as glycolysis). This didn’t make sense to Dr. Warburg as oxygen-fueled metabolic processes (oxidative phosphorylation) in cells were more efficient at generating energy for things like cell growth and proliferation, but repeated experiments by him showed that cancer cells generate lactic acid as a metabolic fuel via glycolysis and use this to help fuel growth, insure their survival, to multiply and to spread. Warburg concluded that it is a major player in cancer development and dubbed it “the Warburg effect”.

Dr. Warburg, who had joined the Kaiser Wilhelm  Institute (Berlin) in 1914 and eventually became head  of  its Cell Physiology Research Laboratory, won the Nobel Prize in Physiology in 1931 for discovering the role of specific enzymes involved in oxygen transfer in cells.

In January 1933 Adolf Hitler was appointed chancellor of Germany and, upon the death of Wiemar Republic President Paul Von Hindenburg in August 1934, combined the offices of chancellor and President into that of Fuehrer. In September 1935 the racist and antisemitic Nuremberg Laws were enacted by the Reichstag during the annual NSDAP (Nazi party) party rally in Nuremberg . Dr. Warburg, who was descended on his father’s side from Orthodox Jewish grandparents, could have easily been deported under German law but was not only left unmolested throughout the 12 year Reich but appears to have enjoyed the protective influence of men in industry who held high rank in the SS as well as Reichsmarshall Herman Goering (who had Dr. Warburg reclassified as 25% Jewish simply because “I decide who is a Jew”). Some historians have linked Hitler’s fear of developing cancer (which took the life of his mother) as well as a similar oncophobia in his Minister of Propaganda & Public Enlightenment, Dr. Paul Joseph Goebbels, to Dr. Warburg’s escaping deportation or worse (Some of Warburg’s relatives did not fare as well including one cousin and her mother who died in Sobibor and another cousin who died in Auschwitz).

Dr. Warburg outlived the Third Reich by almost a quarter century and during his lifetime published over 500 papers and five books. While he insisted the Warburg effect was the point of origin for cancer, the discovery of the molecular structure of DNA by James Watson and Francis Crick in 1953 put genes in the limelight and soon labs and research centers were linking deleterious mutations in specific genes to a wide range of inherited and acquired diseases and medical conditions including many forms of cancer. The Warburg effect was not just eclipsed by this focus on genes but actually was rarely mentioned in textbooks outside of a footnote or as a historical oddity.

Warburg died in 1970 having never proved that his “Warburg effect” triggered cancer. Evidence such as it was during this period of time suggested the Warburg effect was the result and not cause of roughly 80% of all cancer. But for some researchers and even a handful of medical mavericks and “fringe practitioners”, it was a vulnerability or Achilles Heel that could in theory be exploited to induce tumor cell die off.

One of these researchers was a NASA scientist, Clarence Cone, Jr., Ph.D., who filed for and received US patents [#s 4,724,230 (1988), 4,724,234 (1988), and 4,935,450 (1990)] on a method he pioneered which involves manipulating various metabolic and biochemical pathways in solid tumors such that they churn out prodigious quantities of lactate (lactic acid). This is achieved using a specific dietary regimen plus various synthetic and natural drugs. In addition, lactate export from tumors is blocked by he plant bioflavonoid quercitin which results in a lethal drop in intratumor pH (In short, they become too acidic to survive).

Dr. Cone included case histories of patients with various kinds of cancer who’d achieved partial and complete remission on his method in his patent applications. 

In 1989 I came across Dr. Cone’s body of work and immediately spotted a shortcoming: namely that it is hypoxic (low oxygen containing) clusters within certain solid tumors – and not the entire tumor – which synthesizes and exports lactic acid. Dr. Cone’s therapy is thus effective in helping eradicate hypoxic intratumor cell communities but did not generally produce die-off in the non-hypoxic regions of solid tumors.

My insights into how to improve Dr. Cone’s method gave birth to what I dubbed “The Metabolic Oncolytic Regimen” (MOR) which was published online by a website devoted to freely sharing ideas and papers from the realm of biomedical theory.

The MOR was subsequently employed by a handful of oncologists in the US and abroad resulting in numerous cases of partial and total remission in patients with solid tumors, most classified as advanced metastatic cases and some end-stage.

By 1995 my regimen had attracted the attention of scientists at the Office of Alternative Medicine (later reborn as the National Center for Complementary & Alternative Medicine and then the National Center for Complementary and Integrative Health) which resulted in my being funded to attend the historic Practice Outcomes Monitoring and Evaluation System (POMES) cancer conference in 1996, which I did. During the same year the President and Faculty Senate of the Open International University of Complementary & Alternative Medicines, a small integrative medical school in Sri Lanka, awarded me an honorary MD degree and 2 gold medals in science in recognition of the promise of the MOR in metabolic oncology.

This flurry of recognition proved short-lived, however. With the revival of interest by mainstream scientists and doctors in the Warburg effect following the publication of various laboratory studies that showed it could be exploited to eradicate certain tumor cell types, my MOR was quickly eclipsed and largely forgotten.

What I propose to do is document the pioneering metabolic oncology work of “unsung heroes” like Dr. Cone and bring this to light in the form of a book.

A 2 decade long quest: healthspan extension by the spoonful

My challenge is how to get my blue goo to market without winding up having some corporation or corrupt money-grubbing entrepreneur take my brainchild and gouge consumers. I am not interested in helping the 1% (multi-millionaires and billionaires) get richer. My vision is to get the blue goo into the hands & stomachs of common folks (People who work for a living and need help to prevent lifestyle & chronic diseases and medical conditions).

Crowdfunding is one approach, yes, but I am wondering what others work as well or better? If you know of one or more email moi at nativescienceguy at

Noninvasive devices that reduce pain, tremors (Parkinson’s disease), and more!

Innovations worth checking out (2 pages) – August 2019

Check out my 2 page newsletter on noninvasive technologies for pain control, reduction/elimination of tremors in Parkinson’s patients, interactive soundscapes for tinnitus, anxiety & etc. (Good stuff I am merely reporting on, not making money off of!)

Almonds, Vitamin K, Oats, Thyme

Almonds: Health Benefits, Nutrition and Precautions

Vitamin K Health Benefits and Signs of Deficiency

What Makes Oats the Perfect Addition to Your Weight-Loss Diet

10 Science-based Health Benefits of Thyme

Seeds, by George

7 benefits of vitamin K you need to know about

CFC - Vitamin K

Something Amiss

Skewed: Bias, Corruption & Hypocrisy in Contemporary Science & Medicine

HARM: Side & adverse effects of conventional medicine & hospitals vs. natural (alternative medicine or CAM) health care practitioners and supplements & Side & adverse effects of natural & wholistic health care practices & supplements (A Compendium)


All blog entries: Categorized with links



How much vitamin C should one take?

Vitamin CRecently I was asked (on Facebook) how much vitamin C I take, which begs the question: What is the optimal intake of vitamin C for most people?

This is from my Facebook reply:

In order to answer this, I need to jump in the Way Back machine:

Back when I was studying for my doctorate in nutritional medicine (mid 1980s) there was a spirited debate going on among researchers, doctors, nutritionists and others concerning how much vitamin C a human being needed and could handle. Because I came into the realm of human nutrition with a background in biological anthropology (BS, MA) – training I actually undertook purposely not only because I dearly love bio anthro but also because I consider the insights and tools it provides foundational to understanding evolutionary players in human health & disease (and by virtue of this helpful in setting the stage for medical or paramedical studies) – I looked at the quantities of vitamin C produced in mammals that have retained the capacity to do so (Humans and many other primates such as gorillas lost this ability long ago). What emerged is that most nonhuman primates synthesis 25 mg of vitamin C per kilogram of body weight. If one applies this figure to an average (70 kg) human, this comes out to 1750 mg total daily.

There are, of course, mitigating factors. We know 70-90% of the vitamin C people get from food and supplemental forms are absorbed. However, too much taken all at one time reduces absorption! (If you take 1 gram of vitamin C only 50% will be absorbed). However, people with certain chronic diseases appear to absorb and use more even at high intakes.

With all this said, conventional thinking indicates that any amount of vitamin C over 180 mg daily will exceed what the tissues throughout the body can handle (i.e., saturation is reached) and the excess will be processed by the kidneys and dumped in the urine.

After years of dealing with people with chronic diseases, I have come to believe they should be taking 1750 mg to as much as 4 grams of vitamin C in divided doses daily (as their bodies can handle so much more C and apparently need this to support innate disease fighting processes). For healthy young to middle-aged folks, 180 mgs in divided doses or in slow or time release form should be adequate to meet the body’s demands for vitamin C.

Now to your specific question: How much C do I take daily? 500 mg Metabolic C in divided doses (100 mg every 3 hours from morning until evening). I take more than the 180 mg I mentioned above because I am getting older (62) and believe additional C is a good preventative measure as chronic disease processes are often subtlety at work (in even the healthiest of us) with increasing age.

Some folks argue for mega dosing – to “bowel tolerance” – whether healthy or not – which I think is a bit reckless (Most do it to “prevent various diseases especially cancer”). Vitamin C works as an antioxidant at low doses but can promote the production of ROS (reactive oxygen species) molecules when serum levels are very high. These ROS molecules can damage cell membranes and cause other biophysiological problems. As I recall, Nobel prize winning chemist Dr. Linus Pauling ingested mega doses of C daily for years on end. He lived to be 93 but died of prostate cancer. Some have argued his disease was triggered by his mega dosing on C. Dr. Pauling contended his high dose C kept his cancer at bay for years. One thing is certain: Years before Pauling’s’ demise, controlled studies were carried out to see if high dose C impacted various forms of cancer in animals and humans. The bottom line: It was ineffective. Advocates of high dose use of C rejected these studies for various reasons, while most of the scientific community accepted them as valid. The debate goes on to this day in various quarters

A parting word of advice: Do not “super mega dose” to prevent or treat disease. Those individuals reading this who have cancer and are considering using vitamin C to fight it should peruse 

And so it goes……as do I…….

Natural support for congestive heart failure


Congestive heart failure (CHF) or heart failure (HF) refers to reduced or compromised heart function such that the output of blood is inadequate to meet the body’s oxygen demands. There are many conditions that lead to CHF: Hypertension, failure of heart valves to work properly, congenital malformations, hardening of the arteries (arteriosclerosis), infections, constrictive infection of the lining around the heart (pericarditis), and hyperthyroidism. 

The symptoms of CHF vary according to the side of the heart affected — left or right. The most common symptoms are shortness of breath, cardiac asthma (an asthma-like condition caused by heart failure), edema (build-up of fluid in various body parts), cyanosis (bluish color to lips, nose, etc., caused by lack of oxygen), and cardiac hypertrophy (heart enlargement).

Conventional medical treatment varies with the cause, but often includes such therapeutic measures as rest; use of oxygen; improvement of heart muscle contractibility by use of certain drugs such as digitalis and diuretics; sodium restriction; and correction of heart arrhythmias.

Is there anything natural medicine can offer in terms of prevention or treatment of this insidious health challenge? Published research indicates “yes” to both.

To read the rest of this article, go to

Of PQQ, Nutcracker Man & Tiger Nuts (PQQ as radioprotective with heart & nervous system benefits)


Pyrroloquinoline quinone - Wikpedia

Pyrroloquinoline quinone – Wikpedia

I have worked with a coenzyme called pyrroloquinoline quinone (PQQ) for quite a while now and think it is worth a “look see” by physicians and others for its preventative and therapeutic potential. Let’s dive into this now:

First, let’s “do the time warp, now”: During 1994-5 I worked in an Ag lab and large greenhouse complex outside Lincoln, Nebraska (Which was devoted to the testing of various nature-derived growth accelerants on culinary & medicinal mushrooms). One of the principle consulting researchers who rubbed elbows with me was Andy Anderson, PhD, who discovered a radioresistant bacterium back in 1956 while irradiating food at the Oregon Agricultural Experimental Station in Corvallis (As I recall from our chitchat, he was irradiating canned foods to see if this would reliably preserve them against spoilage). The bacterium was subsequently dubbed Deinococcus radiodurans and is indisputably the most radioresistant organism discovered to-date.

Read the rest of this entry

Looking for treatment options for ALS, heart disease, cancer or eczema?

The Wizard of  MusumenPUBLISHED AS: Stepping out from behind the curtain

Many know me as “Anthony the writer”. Many doctors and clinics and labs know me as “Anthony the theorist”.  Actually a more apt moniker might be “Anthony the behind the scenes guy” as so much of my work is on behalf of companies and individual docs who pay to get my ideas and handiwork and affix their name to it without any mention of my authorship.  All this ghostwriting, ghost-editing and ghost-theorizing has helped carve out a niche for me as, well,…a living, breathing ghost (The working world’s invisible man).

However, some of the ventures and projects I am involved with can now be divulged albeit sans key details that could be ripped off and exploited by corporate competition aka money grubbing predators and scavengers.

Amyotrophic Lateral Sclerosis (ALS): Like cancer ALS is a hellacious nut to crack on all kinds of levels. However, evidence has emerged that suggests the disease is influence by aberrant proteins called prions and disease progress reflects the spread of these prions in the central nervous system (CNS). As part of my consultancy work I crafted an experimental combination drug and nondrug anti-prion regimen which was entrusted to MDs abroad (which they then approved and began using). This plus other novel forms of intervention slowed progression to a crawl in many treated ALS patients and has so far spared all of those treated from compromised respiratory functioning.  Of the handful who have died all of them simply went to sleep one night and didn’t wake up (“A good death” in many people’s book).

Atherosclerosis (Arterial blockage): The challenge of reversing arterial blockage has intrigued and engaged me since the mid-1980s. In fact, back then I was working with a Tibetan herbal formula called PADMA 28 that had accumulated evidence (from lab studies and also  randomized clinical trials) that it significantly reduced players in the arterial plaque-building process. I was, in fact, so impressed by the science that I approached the company that had brought PADMA 28 into the USA from Switzerland (where it is Swiss FDA approved to treated intermittent claudication), Berkley Health Network (BHN – later sold and reborn as Pacific BioLogic, Inc.), and began sharing ideas concerning other applications and experimental uses. It didn’t take long before their principle technical people asked me to serve as a scientific advisor which I did. Later I did experiments in which I took a large group of guinea pigs and divided them into 2 groups: Both ate a high saturated & trans fat rich diet geared to produce artery clogging diet which resulted in significant arterial blockage. However, one also was given PADMA 28 in their chow which eventually reversed their blockage. It did this, I think, because it dropped serum lipids and triglycerides so low that their bodies began mobilizing fats and such from their arterial plague. It also countered arterial and systemic inflammation which is a player in the plaque-building process.

In the years since I have added dietary and other measures to the PADMA 28 (now marketed as PADMA BASIC®) to increase plague reversal. Since I am not a physician and cannot diagnose or prescribe treatments, I have entrusted my ever-evolving ideas & resulting regimens to licensed MDs and DOs for their discretionary use. What has emerged is simply this: Many cases have accrued in which people with significant arterial blockage have demonstrated reversal to the point whereby angina and other symptoms ceased.

Note bene: I have no commercial interest in PADMA in any of its incarnations nor in any firm or such that markets or sells it.

Cancer especially advanced metastatic malignancy: Back in 1999 Wake Forest University researcher Zheng Cui, MD, PhD showed that there are super cancer-fighting immune cells called granulocytes in young animals that could obliterate cancer in old ones (mice). Borrowing a page from Dr. Cui’s animal work I created a regimen in which I proposed that pooled granulocytes isolated from the blood of young folks would be given daily to advanced cancer patients over a 10 to 14 day period (But given only to those who have exhausted conventional cancer fighting treatments and whose cancer is spreading and is predicted to end their lives in short order).

This approach was entrusted to a group of Mexican hematologists including one of the leading ones in all of Mexico and was approved for experimental clinical use (with the number of granulocytes and the frequency of their infusions to follow a strict protocol I worked out). The types of cancer subsequently treated included prostate, breast, lung, stomach and colorectal.

There is a <1% risk of a graft v. host reaction even months after a treatment cycle is concluded which all the patients doing it were informed of as part of informed consent.

To-date all advanced, end stage cancer patients treated have responded favorably with no graft v. host reactions occurring at all. Half of those treated experienced partial remission and half, full remission. Some have been technically cancer free for many, many years now.

Eczema: Back in the early 1990s J.I. Harper, MD at the Hospital for Sick Children in London, England put an ancient Chinese herbal eczema tea to the test in a double-blind placebo-controlled clinical involving children with eczema. The tea produced a tremendous diminution in itching, pustules, and scales, for example, while the children who sipped the placebo tea (the control group) did not significantly improve.

The herbs in the eczema tea were published but not the amounts of each. I decided to figure out this out carry out my own line of research. I recruited a large number of eczema patients – children, adolescents, and adults – mixed together the botanicals in varying proportions, and then gave out various versions. (Unlike the London study, however, I opted to use an encapsulated form as opposed to a foul-tasting tea).

It took over two years working at it part-time to arrive at the most effective combination for managing eczema, but effective it is! (My results paralleled those seen in the London-based clinical trials). And it’s not effective for eczema, but for other conditions in which certain species of free radicals and highly inflammatory substances called leukotrienes and prostaglandins play a role. The conditions which have shown a significant response to the eczema formula include asthma, emphysema, psoriasis, certain rheumatic conditions, and numerous neurological maladies.

I turned over the Eczema or E-Tea formula to a company I was consulting for at the time, Prestige Chinese Teas, in 1993. I’d known and collaborated with PCT founder and President Sunny Wong since 1986 and knew he’d so all he could to get E-Tea into the hands of medical consumers at a cost they could afford, which he did. I did not ask for and ever received any proceeds from the sale of E-Tea (as I did not want to add to its cost by doing so) and ceased to be paid as a consultant for PCT in 1999 when I left the USA to teach in Japan. As I anticipated, PCT has continued to make E-Tea available at a cost that is kind to consumer purse strings:

Sunny and his people have received many, many letters and statements from eczema patients, nurses and dermatologists down through the years attesting to E-Tea’s efficacy.

There are many more vexing medical challenges I have tackled down through the years (as a theorist) and a whole litany of them which has been placed on my plate by doctors, companies and even sufferers seeking answers that I am currently working on. And while I “live and move and have my being” for the most part in the Shadowlands you may come across my solutions down the line — albeit you likely will not know I am behind it.

© 2014 by Anthony G. Payne. All rights reserved.

Can an ancient Chinese herbal blend turn the tables on eczema?


Dr. Anthony G. Payne

HERB BLEND - FREE MSOne of the more rewarding aspects of natural products work is finding a viable treatment for a human malady; one which cannot be readily managed using standard pharmaceutical drugs. Thus was the case in 1990 with the discovery that a rather ancient Chinese traditional botanic formula produced noticeable improvement in atopic eczema in children. This observation was reported by J.I. Harper, MD, Department of Pediatric Dermatology, Hospital for Sick Children, London, England, in a letter published in the prestigious scientific journal, “The Lancet“. A list of ingredients employed in the Chinese tea was divulged, but not their proportions.

In 1993, a double-blind placebo-controlled clinical trial of the Chinese eczema tea and pediatric atopic eczema was performed by Dr. Harper and fellow researchers at the Hospital for Sick Children. Most of the children who drank the “real McCoy” (the experimental group) experienced a tremendous diminution of itching, pustules, and scales, for example, while those who sipped the placebo (the control group) did not significantly improve.

A subsequent one-year study was carried out, as described in this quote from a PubMed (medical database) abstract:

“The opportunity to continue treatment was offered to the parents of 37 children who had completed a double-blind placebo-controlled trial of a specific formulation of Chinese medicinal herbs for atopic eczema. The parents elected for continued treatment in every case, and the progress of the children was monitored over the following 12 months. The aim was to achieve a substantial clinical improvement, and thereafter to reduce treatment frequency progressively while maintaining this benefit.

“At the end of the year, 18 enjoyed at least 90 percent reductions in eczema activity scores, and five showed lesser degrees of improvement. Fourteen children withdrew from the study, 10 due to lack of response, and four because of unpalatability of treatment or difficulty in the preparation of treatment.

“By the end of the year, seven of the children were able to discontinue treatment without relapse. The other 16 required treatment to maintain control of their eczema, but only four of these still required daily treatment. Asymptomatic elevation of serum aspartate aminotransferase to 7-14 times normal values was noted on one occasion in two children whose eczema was so well controlled that the therapy was stopped. Liver function tests were normal 8 weeks later.

“We conclude that Chinese medicinal herbs provide a therapeutic option for children with extensive atopic eczema which has failed to respond to other treatments. In the medium term, it proved helpful for approximately half the children who originally took part in our placebo-controlled trial.” (Sheehan MP-Atherton DJ, “One-year follow up of children treated with Chinese medicinal herbs for atopic eczema,” Br J Dermatol, 1994 Apr, Volume: 130, pp. 488 through 493).

Again, the herbs in the eczema tea were disclosed but not the amounts of each. I decided to figure this out and as part of this recruited a large number of eczema patients – children, adolescents, and adults – mixed together the botanicals in varying proportions, and then gave out various versions. (Unlike the London study, however, I opted to use an encapsulated form as opposed to a foul-tasting tea).

It took over two years working at it part-time to arrive at the most effective combination for managing eczema, but effective it is! (My results paralleled those seen in the London-based clinical trials). And it’s not effective for eczema, but for other conditions in which certain species of free radicals and highly inflammatory substances called leukotrienes and prostaglandins play a role. The conditions which have shown a significant response to the eczema formula include asthma, emphysema, psoriasis, certain rheumatic conditions, and numerous neurological maladies.

One memorable and very telltale case involved a Vietnam veteran who presented with a rash and pustules over 90 percent of his body. The physicians at the V.A. center in Dallas were unable to effectively manage the condition, despite prescribing heavy doses of oral steroids coupled with liberal application of various topical drugs. I started this gentleman on one “eczema tea formula” capsule, 3 times each day for the first two weeks; then increased the dosage to two capsules 4 times daily. Within eight weeks of commencing the course of therapy, the rash and pustules had faded and essentially dried up. After another 3-4 weeks, he had virtually no visible evidence of what had been an almost three-decade nightmare.

One need only read about various skin conditions to realize the pervasiveness of this exasperating, debilitation dermatological challenge. For me, however, there is far more than a realization of how ubiquitous eczema is. As a boy I suffered from one of the worst cases of eczema imaginable. Even the steroid hormone, cortisone, didn’t help. Thankfully, my eczema went into permanent remission after age 5 or so, but I never forgot the more than three years I spent combating this nightmarish condition. And while it took me almost 36 years to turn my attention back to this human malady, the victory is no less sweet.

Nota bene: I turned over the Eczema or E-Tea formula to a company I was consulting for at the time, Prestige Chinese Teas, in 1993. I’d known and collaborated with PCT founder and President Sunny Wong since 1986 and knew he’d so all he could to get E-Tea into the hands of medical consumers at a cost they could afford, which he did. I did not ask for and ever received any proceeds from the sale of E-Tea (as I did not want to add to its cost by doing so) and ceased to be paid as a consultant for PCT in 1999 when I left the USA to teach in Japan. As I anticipated, PCT has continued to make E-Tea available at a cost that is kind to consumer purse strings:

 ©2014 by Dr. Anthony G. Payne. All rights reserved.

Sickle cell disease: Antisickling herbs

OPTIONS 7If any of you reading this has sickle cell disease or knows someone who does, this may be of interest. A few days ago, one of my female African-American Facebook friends asked if I had ever been involved in the research or treatment of sickle cell disease. This was my response:

In answer to your question: I have not been involved in doing any kind of work on sickle cell disease. However, I am aware of progress that has been made in terms of screening for potential new drugs as well as genetic engineering experiments. This kind of thing, however, is years if not decades away from any sort of approval (After Phase I and then phase II studies are completed and a consensus as to safety & outcome is reached in the scientific & medical communities). I assume you know people touched by sickle cell disease and are interested in “here and now treatments”. Well, there are some from the world of herbal medicine, many having originated with African traditional healers with some of these having undergone phase I/II studies. I ran across a review paper covering this at…/P…/pdf/TSWJ2013-269659.pdf. Check it out, as they say.

What intrigued me was the antisickling activity of a Nigerian plant-based formula called “Ciklavit” (Perhaps you are acquainted with it). I did some digging and came up with a Pharma firm in Nigeria that sells Ciklavit:…/ethica…/ciklavit/

I was also impressed by the reports on the antisickling activity of dried Papaya leaves which is sold OTC and cheap here in the USA. Swanson sells bottles f it for a pittance at…

Nota bene: I have no financial or other commercial interests in the Nigerian firm mentioned above nor Swanson vitamin company.

Choctaw Doc

Reversing arterial blockage: Experimental regimen that worked for man facing amputation of his lower legs

Dr Payne at the Zeiss MicroscopeLast year (2012) I was contacted by a gentleman who had severe blockage in his legs and had been told by his physician-surgeon that he would need to amputate his legs below the knee. Naturally this chap was horrified at the prospect of living his life out of a wheelchair and/or on crutches and was frantic to know if there is anything, however experimental, that might help him avoid the surgeon’s knife. Apparently he had done a Google search and come across some of my health-related hypotheses (I have since 1986, been paid by various docs & researchers to spin hypotheses and provide novel ideas they could then pursue – or not).

I could not, of course, prescribe anything whatsoever as I am not a physician and lack the qualifications to get into such matters. However, what I did do is hand off an experimental regimen I originally developed in the late 1980s and had updated recently, along with the stringent caveat that much of my own work and that which informed it involved animal models of arterial blockage and I was giving him this with the strict understanding he would share it with his primary care MD and do what he said or advised.

I heard nothing from this chap for about 8 months and then got a call. It seems he was able to get his MD to endorse my handwork which he had followed religiously.  Long story short, the circulation in his legs had improved to the point that amputation was no longer on the proverbial table. Needless to say he and his wife of some 50+ years were overjoyed by his progress.

So here is what I shared with this guy – again, with the caveat it is experimental and unproved and should not be undertaken without the express consent & supervision of a duly licensed & practicing MD or DO.    

Dr. Anthony G. Payne


PADMA: Scientifically validated Tibetan herbal blend


Back in the 1980s I served as a scientific advisor to the firm (Berkley Wellness Network) that first brought the Tibetan vasocative product PADMA28 into the USA (BHN was bought by businessman Curtis Jaquot in the early 1990s and became “Pacific BioLogic, Inc.) In the mid-1990s I fed PADMA28 laced chow to guinea pigs with induced arterial blockage. Animals fed high doses showed a reversal of blockage.    

Note: I have no financial or other commercial interest in PADMA or any firm that makes, sells, markets, distributes or otherwise promotes it.

My 2007 article on PADMA 28:

PubMed search results:

Is bias, corruption & hypocrisy now normative in science & medicine?

HARM &amp; SKEWED 2016

NEJM editor: “No longer possible to believe much of clinical research published”

Eradicating cancer: Metabolic monkey wrenching including use of autophagy inhibitors

On 9-6-2012 ScienceDaily ran this article: Microenvironments in Tumors Aid Tumor Cell Survival, Researchers Find

Here is a link to the full paper(Cancer Res 2012;72:3938-3947. Published Online First June 19, 2012) for those interested in perusing this:  – Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

Interestingly, my Metabolic Oncolytic Regimen (original body of theory – 1990 — various permutations since) is based on lowering pH in hypoxic regions of solid tumors to lethal levels:

However, as the paper in the Cancer Research Journal (link above) signals, tumor cells in acidic regions adapt and survive by chronically activating autophagy pathways. Thankfully though, this can be circumvented by use of autophagy inhibitors: combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells of Autophagy inhibitors (Sigma Chemical) including N-acetyl-cysteine Autophagy Inhibitors – Tocris Bioscience

Hydroxychloroquine and chloroquine are autophagy inhibitors. 2: Autophagy inducers and inhibitors for cancer treatment

This line of work & reasoning suggests that a marriage of the MOR (or a similar “metabolic anti-tumor monkey wrenching” approach) with one or more autophagy inhibitors should deliver a death blow to at least some solid tumors. 




HARM: A compendium

HARM: A compendium of statistics & information  (Harm done by conventional health care v. AltMed practices & supplements)     
Web address: 
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