Using bacteria in tumors to eradicate them

BY LARRY LUXNER JULY 27, 2020 11:46 AM

While bacteria were first detected in human tumors more than 100 years ago, Straussman reported in a paper in the May 29 issue of Science that he found bacteria live inside the cells of many cancer types, and that each type of cancer houses unique populations of bacteria.

Breast cancer, which has a relatively high incidence among Jewish women, has a particularly rich and diverse microbiome.

“We believe we can induce an environment where cancer cannot develop,” she said. “Maybe in the future bacteria that stimulate the immune system can be added to immune therapy, so that the cancer can be eradicated more quickly and efficiently.”

Click to read the entire article: https://www.jta.org/2020/07/27/health/israeli-scientists-identify-new-culprit-behind-cancerous-growths-tumor-specific-bacteria

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The Israeli scientists posit one approach to eradicating tumors. In 2005 I proposed using specific bacteria to facilitate the electromagnetic heating of tumors to the point of die-off. A quote from my paper and a link to same follow below.

PREVENTING METASTASIS AND ACHIEVING ONCOLYSIS IN SOLID TUMORS BY INHIBITING SPECIFIC METALLOPROTEINASES AND MANIPULATING KEY METABOLIC PATHWAYS. A. G. PAYNE [2005] MED HYPOTHESES RES 2: 553-565.

One permutation to this approach that might prove of utility: Introduce magnetotactic bacterial vectors in vivo which have been genetically engineered or artificially selected to seek out and bind to specific tumor cell antigens. If achievable, the magnetotactic bacteria might provide sufficient iron once inside tumor cells to make achieving electromagnetic heating more certain.

Click to access manipulating-metalloproteinases-to-achieve-oncolysis-med-hyp-and-res.pdf

Eradicating cancer: Metabolic monkey wrenching including use of autophagy inhibitors

On 9-6-2012 ScienceDaily ran this article:  http://www.sciencedaily.com/releases/2012/09/120906074249.htm – Acidic Microenvironments in Tumors Aid Tumor Cell Survival, Researchers Find

Here is a link to the full paper(Cancer Res 2012;72:3938-3947. Published Online First June 19, 2012) for those interested in perusing this: http://cancerres.aacrjournals.org/content/72/16/3938.full.pdf+html  – Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

Interestingly, my Metabolic Oncolytic Regimen (original body of theory – 1990 — various permutations since) is based on lowering pH in hypoxic regions of solid tumors to lethal levels: http://www.healingcare4u.org/The%20Metabolic%20Oncolytic%20Regimen%20(Revised%202011).pdf

However, as the paper in the Cancer Research Journal (link above) signals, tumor cells in acidic regions adapt and survive by chronically activating autophagy pathways. Thankfully though, this can be circumvented by use of autophagy inhibitors:   

http://www.landesbioscience.com/journals/autophagy/BenSahraAUTO6-5.pdf – The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

http://www.jbc.org/content/281/46/34870.full.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557039/

http://www.sigmaaldrich.com/life-science/cell-biology/cell-biology-products.html?TablePage=104899425 –List of Autophagy inhibitors (Sigma Chemical) including N-acetyl-cysteine

http://www.tocris.com/pharmacologicalBrowser.php?ItemId=296970&Type=Inhibitors – Autophagy Inhibitors – Tocris Bioscience

Hydroxychloroquine and chloroquine are autophagy inhibitors.

http://www.nature.com/nbt/journal/v30/n7/fig_tab/nbt.2285_T2.html – Table 2: Autophagy inducers and inhibitors for cancer treatment

This line of work & reasoning suggests that a marriage of the MOR (or a similar “metabolic anti-tumor monkey wrenching” approach) with one or more autophagy inhibitors should deliver a death blow to at least some solid tumors.