During March of this year (2013) a paper appeared in the journal The Lancet titled “Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations”. You may have seen something about this among the many news articles and blurbs posted across the Web on the heels of this paper’s publication. If not, check out Science Daily’s excellent lay level piece on it at http://www.sciencedaily.com/releases/2013/03/130311091537.htm
You can read the paper in its entirety at http://download.thelancet.com/flatcontentassets/pdfs/S014067361360598X.pdf I perused it right after it came out and would like to share my thoughts on a possible culprit behind the arterial blockage that bedeviled the ancient peoples represented in the Horus study and which has cast a long shadow over modern populations as well (The fabled “Iceman“ Ötzi showed evidence of atherosclerosis too albeit he had a genetic predisposition and evidence of a chronic infection, namely borreliosis or Lyme disease).
Why are some folks naturally multiorgasmic? Female biologic advantages aside, the key player appears to be prolactin. Various studies have shown that prolactin is released at orgasm and plays a role in post-orgasmic sexual “repose”. Conversely, various other studies have shown that people with low or almost nonexistent prolactin levels can have orgasm after orgasm after orgasm ad infinitum. Is there any way in which to safely lower prolactin levels and thus help facilitate becoming multi-orgasmic? Perhaps so (The drug bromocriptine can accomplish this, but has side effects that may argue against its use in many folks). The medicinal herb Chaste Tree Berry (Castes Agnes-Vitex) has been shown to reduce prolactin levels in human users.
Kruger TH, Haake P, Haverkamp J, Kramer M, Exton MS, Saller B, Leygraf N, Hartmann U, Schedlowski M, ‘Effects of acute prolactin manipulation on sexual drive and function in males,’ J Endocrinol. 2003 Dec;179(3):357-65.
Haake P, Exton MS, Haverkamp J, Kramer M, Leygraf N, Hartmann U, Schedlowski M, Krueger TH, ‘Absence of orgasm-induced prolactin secretion in a healthy multi-orgasmic male subject’, Int J Impot Res. 2002 Apr;14(2):133-5.
Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlova-Wuttke D,’ Chaste tree (Vitex agnus-castus)–pharmacology and clinical indications’, Phytomedicine. 2003 May;10(4):348-57.
If you have recently been jilted or otherwise had a close relationship severed, you are undoubtedly feeling the loss and perhaps even a wee bit of rage (Which actually serves a purpose insofar as it helps one purge the other from one’s life). Your brain is actually going through withdrawal involving the selfsame neurochemical players and brain centers that are involved in reward and addiction. In a nutshell, your dopamine levels are plummeting (sets off cravings), the mood modulator serotonin has taken a nose dive (Blue Funk time), stress hormones are up and there may even be withdrawal symptoms associated with opioid compounds you produced (and augmented via behavior & diet) which you body is now clamoring for. The passage of time in concert with physical activity will help take the punch out of this biochemical maelstrom (More on this can be found in chapter 8 of Anatomy of Love: A Natural History of Mating, Marriage, and Why We Stray )
Here are a few non-pharmaceutical measures that may help:
To help raise dopamine levels in the brain:
Muncuna (Mucuna pruriens) products such as http://www.iherb.com/Mucuna
Diet: Eat prepared Fava beans (A legume)
To help raise serotonin levels in the brain:
5-hydroxytryptamine (5-HTP) http://www.biopsychiatry.com/tryptophan-5htp.htm
Diet: Eat lots of turkey (Tryptophan source – precursor used to generate serotonin)
Take with pyridoxal-5 phosphate – 10 mgs. (A form of B6)
To help modulate stress hormones:
Standardized Ginseng Extract (Panax ginseng)
To help curtail endogenous opioids (Compounds generated in one’s body that influence reward and addiction):
Follow the Paleodiet (Fava beans excepted) http://14ushop.com/wizard/living-longer.html
Ask your doctor about putting you on low dose Naltrexone
N-acetyl-Tyrosine, DL-Phenylalanine http://www.lef.org/protocols/prtcl-089.shtml (Folks with PKU or hypertension should avoid DL-Phenylalanine)
Manyam BV, Dhanasekaran M, Hare TA, ‘Neuroprotective effects of the antiparkinson drug Mucuna pruriens’, Phytother Res. 2004 Sep;18(9):706-12
Apaydin H, Ertan S, Ozekmekci S, ‘Broad bean (Vicia faba)–a natural source of L-dopa–prolongs “on” periods in patients with Parkinson’s disease who have “on-off” fluctuations’, Mov Disord. 2000 Jan;15(1):164-6
Kaneko H, Nakanishi K, ‘Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, korean red ginseng: specifically, its anti-stress action for prevention of disease,’ J Pharmacol Sci. 2004 Jun;95(2):158-62.
Kim DH, Jung JS, Suh HW, Huh SO, Min SK, Son BK, Park JH, Kim ND, Kim YH, Song DK,’ Inhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: involvement of nitric oxide,’ Neuroreport. 1998 Jul 13;9(10):2261-4.
Zioudrou C, Streaty RA, Klee WA, ‘Opioid peptides derived from food proteins. The exorphins,’ J Biol Chem. 1979 Apr 10;254(7):2446-9.
Fukudome S, Yoshikawa M., ‘Opioid peptides derived from wheat gluten: their isolation and characterization,’ FEBS Lett. 1992 Jan 13;296(1):107-11
‘Neuroendocrine effects of SAMe, a novel putative antidepressant,’ J Psychiatr Res, 1990, 24:2.
De Vanna M, Rigamonti R, ‘Oral SAMe in depression’, Curr Ther Res 1992, 52: 478-485.