Eradicating cancer: Metabolic monkey wrenching including use of autophagy inhibitors
Posted by Dr. Anthony G. Payne
On 9-6-2012 ScienceDaily ran this article: http://www.sciencedaily.com/releases/2012/09/120906074249.htm – Acidic Microenvironments in Tumors Aid Tumor Cell Survival, Researchers Find
Here is a link to the full paper(Cancer Res 2012;72:3938-3947. Published Online First June 19, 2012) for those interested in perusing this: http://cancerres.aacrjournals.org/content/72/16/3938.full.pdf+html – Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments
Interestingly, my Metabolic Oncolytic Regimen (original body of theory – 1990 — various permutations since) is based on lowering pH in hypoxic regions of solid tumors to lethal levels: http://www.healingcare4u.org/The%20Metabolic%20Oncolytic%20Regimen%20(Revised%202011).pdf
However, as the paper in the Cancer Research Journal (link above) signals, tumor cells in acidic regions adapt and survive by chronically activating autophagy pathways. Thankfully though, this can be circumvented by use of autophagy inhibitors:
http://www.landesbioscience.com/journals/autophagy/BenSahraAUTO6-5.pdf – The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
http://www.sigmaaldrich.com/life-science/cell-biology/cell-biology-products.html?TablePage=104899425 –List of Autophagy inhibitors (Sigma Chemical) including N-acetyl-cysteine
http://www.tocris.com/pharmacologicalBrowser.php?ItemId=296970&Type=Inhibitors – Autophagy Inhibitors – Tocris Bioscience
http://www.nature.com/nbt/journal/v30/n7/fig_tab/nbt.2285_T2.html – Table 2: Autophagy inducers and inhibitors for cancer treatment
This line of work & reasoning suggests that a marriage of the MOR (or a similar “metabolic anti-tumor monkey wrenching” approach) with one or more autophagy inhibitors should deliver a death blow to at least some solid tumors.
About Dr. Anthony G. PayneI am a word & ideas weaver, hypothesis spinner, artist, Celtic Catholic monk, long time member of MENSA, and a BIA certified American Indian and tribal member of the Choctaw Nation of Oklahoma. You can readily reach me by shooting an e-mail to firstname.lastname@example.org.
Posted on September 6, 2012, in CAM - Complementary Alternative Medicine, Cancer and tagged autophagy and cancer, autophagy inhibitors, cancer treatment, cancer treatment alternatives, metabolic oncology, metabolic oncolytic regimen, pH and cancer, Warburg Effect. Bookmark the permalink. Comments Off on Eradicating cancer: Metabolic monkey wrenching including use of autophagy inhibitors.
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