Eradicating cancer: Metabolic monkey wrenching including use of autophagy inhibitors
Posted by Dr. Anthony G. Payne
On 9-6-2012 ScienceDaily ran this article: http://www.sciencedaily.com/releases/2012/09/120906074249.htm – Acidic Microenvironments in Tumors Aid Tumor Cell Survival, Researchers Find
Here is a link to the full paper(Cancer Res 2012;72:3938-3947. Published Online First June 19, 2012) for those interested in perusing this: http://cancerres.aacrjournals.org/content/72/16/3938.full.pdf+html – Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments
Interestingly, my Metabolic Oncolytic Regimen (original body of theory – 1990 — various permutations since) is based on lowering pH in hypoxic regions of solid tumors to lethal levels: http://www.healingcare4u.org/The%20Metabolic%20Oncolytic%20Regimen%20(Revised%202011).pdf
However, as the paper in the Cancer Research Journal (link above) signals, tumor cells in acidic regions adapt and survive by chronically activating autophagy pathways. Thankfully though, this can be circumvented by use of autophagy inhibitors:
http://www.landesbioscience.com/journals/autophagy/BenSahraAUTO6-5.pdf – The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
http://www.sigmaaldrich.com/life-science/cell-biology/cell-biology-products.html?TablePage=104899425 –List of Autophagy inhibitors (Sigma Chemical) including N-acetyl-cysteine
http://www.tocris.com/pharmacologicalBrowser.php?ItemId=296970&Type=Inhibitors – Autophagy Inhibitors – Tocris Bioscience
http://www.nature.com/nbt/journal/v30/n7/fig_tab/nbt.2285_T2.html – Table 2: Autophagy inducers and inhibitors for cancer treatment
This line of work & reasoning suggests that a marriage of the MOR (or a similar “metabolic anti-tumor monkey wrenching” approach) with one or more autophagy inhibitors should deliver a death blow to at least some solid tumors.
About Dr. Anthony G. PayneMost of the time you will find me spinning ideas and web content for client firms and especially physicians (MDs and DOs). Among my many passions are helping others help others, word weaving (Published writer & author, ghostwriter, copywriter, proofreader, editor), and art (Mainly sketching. I revel in Jackson Pollock's art and thus enjoy experimenting with his approach combined with those of other artists). Nature is a focus too, reflected in the fact I have been involved in the deep ecology movement since the 1980s and (more recently) the Forest Church movement. I am also a lay Celtic Christian monk (Novice monk in 2015, full monk in 2017). This is the realization of a calling I have "flirted with" for many moons now. You are encouraged to check out my "Summer Cloud's Spiritual Watering Hole" website to learn more: http://summerclouds.weebly.com.
Posted on September 6, 2012, in CAM - Complementary Alternative Medicine, Cancer and tagged autophagy and cancer, autophagy inhibitors, cancer treatment, cancer treatment alternatives, metabolic oncology, metabolic oncolytic regimen, pH and cancer, Warburg Effect. Bookmark the permalink. Comments Off on Eradicating cancer: Metabolic monkey wrenching including use of autophagy inhibitors.
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