Category Archives: MEDICINE

7 benefits of vitamin K you need to know about

https://www.top10homeremedies.com/news-facts/know-vitamin-k-important.html

CFC - Vitamin K

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Something Amiss

Skewed: Bias, Corruption & Hypocrisy in Contemporary Science & Medicine

HARM: Side & adverse effects of conventional medicine & hospitals vs. natural (alternative medicine or CAM) health care practitioners and supplements & Side & adverse effects of natural & wholistic health care practices & supplements (A Compendium)

http://www.something-amiss.org/pdf/SKEWED&HARM-10-2016.pdf

 

SOMETHING AMISS 2016

 

 

All blog entries: Categorized with links

https://biotheorist.files.wordpress.com/2018/07/for-seekers-other-heretics-blog-entries-menu.pdf

SEEKERS & OTHER HERETICS MENU - CATEGORIZED WITH LINKS

 

Progress in the treatment of cancer & ALS

https://ncimexico.files.wordpress.com/2018/05/unsung-heroes-anton-ideenmacher-april-2018.pdf


UNSUNG HEROES NL - May 2018

End stage cirrhosis reversed with nontoxic treatment

https://ncimx.wordpress.com/2018/02/28/nontoxic-treatment-reversed-end-stage-cirrhosis-in-elderly-lady/

CIRRHOSIS BLOG ENTRY - NCIM

 

 

Radio interview with the medical director of the largest private stem cell clinic in California

Click to access Denise Messenger’s 1-31-2018 radio interview with physician David Steenblock

DR Steenblock in blueDR S by bookcase SRI

1m51s video taken in and around Dr. Steenblock’s San Clemente, CA. clinic (Drone shots too)

31m (2011) video in which Dr. Steenblock discusses his use of adult (nonembryonic) stem cells & other modalities to treat chronic diseases & medical conditions (in adults & children):

 

How much vitamin C should one take?

Vitamin CRecently I was asked (on Facebook) how much vitamin C I take, which begs the question: What is the optimal intake of vitamin C for most people?

This is from my Facebook reply:

In order to answer this, I need to jump in the Way Back machine:

Back when I was studying for my doctorate in nutritional medicine (mid 1980s) there was a spirited debate going on among researchers, doctors, nutritionists and others concerning how much vitamin C a human being needed and could handle. Because I came into the realm of human nutrition with a background in biological anthropology (BS, MA) – training I actually undertook purposely not only because I dearly love bio anthro but also because I consider the insights and tools it provides foundational to understanding evolutionary players in human health & disease (and by virtue of this helpful in setting the stage for medical or paramedical studies) – I looked at the quantities of vitamin C produced in mammals that have retained the capacity to do so (Humans and many other primates such as gorillas lost this ability long ago). What emerged is that most nonhuman primates synthesis 25 mg of vitamin C per kilogram of body weight. If one applies this figure to an average (70 kg) human, this comes out to 1750 mg total daily.

There are, of course, mitigating factors. We know 70-90% of the vitamin C people get from food and supplemental forms are absorbed. However, too much taken all at one time reduces absorption! (If you take 1 gram of vitamin C only 50% will be absorbed). However, people with certain chronic diseases appear to absorb and use more even at high intakes.

With all this said, conventional thinking indicates that any amount of vitamin C over 180 mg daily will exceed what the tissues throughout the body can handle (i.e., saturation is reached) and the excess will be processed by the kidneys and dumped in the urine.

After years of dealing with people with chronic diseases, I have come to believe they should be taking 1750 mg to as much as 4 grams of vitamin C in divided doses daily (as their bodies can handle so much more C and apparently need this to support innate disease fighting processes). For healthy young to middle-aged folks, 180 mgs in divided doses or in slow or time release form should be adequate to meet the body’s demands for vitamin C.

Now to your specific question: How much C do I take daily? 500 mg Metabolic C in divided doses (100 mg every 3 hours from morning until evening). I take more than the 180 mg I mentioned above because I am getting older (62) and believe additional C is a good preventative measure as chronic disease processes are often subtlety at work (in even the healthiest of us) with increasing age.

Some folks argue for mega dosing – to “bowel tolerance” – whether healthy or not – which I think is a bit reckless (Most do it to “prevent various diseases especially cancer”). Vitamin C works as an antioxidant at low doses but can promote the production of ROS (reactive oxygen species) molecules when serum levels are very high. These ROS molecules can damage cell membranes and cause other biophysiological problems. As I recall, Nobel prize winning chemist Dr. Linus Pauling ingested mega doses of C daily for years on end. He lived to be 93 but died of prostate cancer. Some have argued his disease was triggered by his mega dosing on C. Dr. Pauling contended his high dose C kept his cancer at bay for years. One thing is certain: Years before Pauling’s’ demise, controlled studies were carried out to see if high dose C impacted various forms of cancer in animals and humans. The bottom line: It was ineffective. Advocates of high dose use of C rejected these studies for various reasons, while most of the scientific community accepted them as valid. The debate goes on to this day in various quarters

A parting word of advice: Do not “super mega dose” to prevent or treat disease. Those individuals reading this who have cancer and are considering using vitamin C to fight it should peruse https://www.cancer.gov/about-cancer/treatment/cam/patient/vitamin-c-pdq 

And so it goes……as do I…….

Natural support for congestive heart failure

CONGESTIVE HEART FAILURE - Natural Support

Congestive heart failure (CHF) or heart failure (HF) refers to reduced or compromised heart function such that the output of blood is inadequate to meet the body’s oxygen demands. There are many conditions that lead to CHF: Hypertension, failure of heart valves to work properly, congenital malformations, hardening of the arteries (arteriosclerosis), infections, constrictive infection of the lining around the heart (pericarditis), and hyperthyroidism. 

The symptoms of CHF vary according to the side of the heart affected — left or right. The most common symptoms are shortness of breath, cardiac asthma (an asthma-like condition caused by heart failure), edema (build-up of fluid in various body parts), cyanosis (bluish color to lips, nose, etc., caused by lack of oxygen), and cardiac hypertrophy (heart enlargement).

Conventional medical treatment varies with the cause, but often includes such therapeutic measures as rest; use of oxygen; improvement of heart muscle contractibility by use of certain drugs such as digitalis and diuretics; sodium restriction; and correction of heart arrhythmias.

Is there anything natural medicine can offer in terms of prevention or treatment of this insidious health challenge? Published research indicates “yes” to both.

To read the rest of this article, go to https://biotheorist.files.wordpress.com/2017/08/natural-health-support-measures-for-congestive-heart-failure-rev-7-31-2017.pdf

Physician shares his bold plan to make healthcare much cheaper

Physician David Steenblock has specific ideas on how to streamline healthcare and make it cheaper in the process. He discusses these in an interview with Risk Group LCC which appears below (You Tube video which runs 1h8sec).

A one page op-ed letter penned by Dr. Steenblock concerning one of his core healthcare reform ideas also  appears below (Clickable graphic & link).

Enjoy and share freely!

 

 

 

https://biotheorist.files.wordpress.com/2017/07/free-health-care-for-all-truncated-version-for-the-sun-post-in-san-clemente2.doc

 

 

Ependyma & CSF & stem cells & ALS: Connect the dots

mri-of-brain-free-msPublic Release: 21-Jul-2016

Unprecedented: Canadian man 10 years out from a devastating stroke does amazing turnaround

http://www.trurodaily.com/News/Local/2015-05-20/article-4152986/Truro-man-gaining-strength-after-stem-cell-treatment/1

“I believe in it and I believe it’s the next generation in medicine, just like penicillin was,” said the Truro resident. “Regardless of what Canada and the U.S. says about it. They don’t know about it. I didn’t know about it, but I know about it now.”

After you have read the Truro Daily News story, go to https://ncimx.wordpress.com/2015/05/10/canadian-man-10-years-out-from-a-stroke-recovers-lost-body-functions-in-7-days-time/  to get additional details & links.

TRURO DAILY NEWS ARTICLE ON DAN HUNTLEY - May  21, 2015 (2)

“Stem cell treatment gives local family new lease on life” (St. Albert Gazette)

http://www.stalbertgazette.com/article/20150228/SAG9604/302289988/-1/sag

ST. ALBERT GAZETTE - ARTHUR RECHLO & NCIM (2-28-2015)

 

From the medical advances department: The Beacon Factor

THE BEACON FACTOR

Video Quickie

Got 2 minutes to spare? Then sit back and enjoy a mix of fact, fantasy & tongue-n-cheek from “yours truly” (Dr. Anthony G. Payne)

 

Of PQQ, Nutcracker Man & Tiger Nuts (PQQ as radioprotective with heart & nervous system benefits)

 

Pyrroloquinoline quinone - Wikpedia

Pyrroloquinoline quinone – Wikpedia

I have worked with a coenzyme called pyrroloquinoline quinone (PQQ) for quite a while now and think it is worth a “look see” by physicians and others for its preventative and therapeutic potential. Let’s dive into this now:

First, let’s “do the time warp, now”: During 1994-5 I worked in an Ag lab and large greenhouse complex outside Lincoln, Nebraska (Which was devoted to the testing of various nature-derived growth accelerants on culinary & medicinal mushrooms). One of the principle consulting researchers who rubbed elbows with me was Andy Anderson, PhD, who discovered a radioresistant bacterium back in 1956 while irradiating food at the Oregon Agricultural Experimental Station in Corvallis (As I recall from our chitchat, he was irradiating canned foods to see if this would reliably preserve them against spoilage). The bacterium was subsequently dubbed Deinococcus radiodurans and is indisputably the most radioresistant organism discovered to-date.

Read the rest of this entry

SHORT VIDEO: Options & Alternatives (Free pointers & help) by Choctaw Doc

Thumbnail 1:26

https://www.youtube.com/watch?v=9tR6iAHCcrc&feature=youtu.be

Looking for treatment options for ALS, heart disease, cancer or eczema?

The Wizard of  MusumenPUBLISHED AS: Stepping out from behind the curtain

Many know me as “Anthony the writer”. Many doctors and clinics and labs know me as “Anthony the theorist”.  Actually a more apt moniker might be “Anthony the behind the scenes guy” as so much of my work is on behalf of companies and individual docs who pay to get my ideas and handiwork and affix their name to it without any mention of my authorship.  All this ghostwriting, ghost-editing and ghost-theorizing has helped carve out a niche for me as, well,…a living, breathing ghost (The working world’s invisible man).

However, some of the ventures and projects I am involved with can now be divulged albeit sans key details that could be ripped off and exploited by corporate competition aka money grubbing predators and scavengers.

Amyotrophic Lateral Sclerosis (ALS): Like cancer ALS is a hellacious nut to crack on all kinds of levels. However, evidence has emerged that suggests the disease is influence by aberrant proteins called prions and disease progress reflects the spread of these prions in the central nervous system (CNS). As part of my consultancy work I crafted an experimental combination drug and nondrug anti-prion regimen which was entrusted to MDs abroad (which they then approved and began using). This plus other novel forms of intervention slowed progression to a crawl in many treated ALS patients and has so far spared all of those treated from compromised respiratory functioning.  Of the handful who have died all of them simply went to sleep one night and didn’t wake up (“A good death” in many people’s book).

Atherosclerosis (Arterial blockage): The challenge of reversing arterial blockage has intrigued and engaged me since the mid-1980s. In fact, back then I was working with a Tibetan herbal formula called PADMA 28 that had accumulated evidence (from lab studies and also  randomized clinical trials) that it significantly reduced players in the arterial plaque-building process. I was, in fact, so impressed by the science that I approached the company that had brought PADMA 28 into the USA from Switzerland (where it is Swiss FDA approved to treated intermittent claudication), Berkley Health Network (BHN – later sold and reborn as Pacific BioLogic, Inc.), and began sharing ideas concerning other applications and experimental uses. It didn’t take long before their principle technical people asked me to serve as a scientific advisor which I did. Later I did experiments in which I took a large group of guinea pigs and divided them into 2 groups: Both ate a high saturated & trans fat rich diet geared to produce artery clogging diet which resulted in significant arterial blockage. However, one also was given PADMA 28 in their chow which eventually reversed their blockage. It did this, I think, because it dropped serum lipids and triglycerides so low that their bodies began mobilizing fats and such from their arterial plague. It also countered arterial and systemic inflammation which is a player in the plaque-building process.

In the years since I have added dietary and other measures to the PADMA 28 (now marketed as PADMA BASIC®) to increase plague reversal. Since I am not a physician and cannot diagnose or prescribe treatments, I have entrusted my ever-evolving ideas & resulting regimens to licensed MDs and DOs for their discretionary use. What has emerged is simply this: Many cases have accrued in which people with significant arterial blockage have demonstrated reversal to the point whereby angina and other symptoms ceased.

Note bene: I have no commercial interest in PADMA in any of its incarnations nor in any firm or such that markets or sells it.

https://biotheorist.files.wordpress.com/2017/08/padma-28-2017.pdf

Cancer especially advanced metastatic malignancy: Back in 1999 Wake Forest University researcher Zheng Cui, MD, PhD showed that there are super cancer-fighting immune cells called granulocytes in young animals that could obliterate cancer in old ones (mice). Borrowing a page from Dr. Cui’s animal work I created a regimen in which I proposed that pooled granulocytes isolated from the blood of young folks would be given daily to advanced cancer patients over a 10 to 14 day period (But given only to those who have exhausted conventional cancer fighting treatments and whose cancer is spreading and is predicted to end their lives in short order).

This approach was entrusted to a group of Mexican hematologists including one of the leading ones in all of Mexico and was approved for experimental clinical use (with the number of granulocytes and the frequency of their infusions to follow a strict protocol I worked out). The types of cancer subsequently treated included prostate, breast, lung, stomach and colorectal.

There is a <1% risk of a graft v. host reaction even months after a treatment cycle is concluded which all the patients doing it were informed of as part of informed consent.

To-date all advanced, end stage cancer patients treated have responded favorably with no graft v. host reactions occurring at all. Half of those treated experienced partial remission and half, full remission. Some have been technically cancer free for many, many years now.

Eczema: Back in the early 1990s J.I. Harper, MD at the Hospital for Sick Children in London, England put an ancient Chinese herbal eczema tea to the test in a double-blind placebo-controlled clinical involving children with eczema. The tea produced a tremendous diminution in itching, pustules, and scales, for example, while the children who sipped the placebo tea (the control group) did not significantly improve.

The herbs in the eczema tea were published but not the amounts of each. I decided to figure out this out carry out my own line of research. I recruited a large number of eczema patients – children, adolescents, and adults – mixed together the botanicals in varying proportions, and then gave out various versions. (Unlike the London study, however, I opted to use an encapsulated form as opposed to a foul-tasting tea).

It took over two years working at it part-time to arrive at the most effective combination for managing eczema, but effective it is! (My results paralleled those seen in the London-based clinical trials). And it’s not effective for eczema, but for other conditions in which certain species of free radicals and highly inflammatory substances called leukotrienes and prostaglandins play a role. The conditions which have shown a significant response to the eczema formula include asthma, emphysema, psoriasis, certain rheumatic conditions, and numerous neurological maladies.

I turned over the Eczema or E-Tea formula to a company I was consulting for at the time, Prestige Chinese Teas, in 1993. I’d known and collaborated with PCT founder and President Sunny Wong since 1986 and knew he’d so all he could to get E-Tea into the hands of medical consumers at a cost they could afford, which he did. I did not ask for and ever received any proceeds from the sale of E-Tea (as I did not want to add to its cost by doing so) and ceased to be paid as a consultant for PCT in 1999 when I left the USA to teach in Japan. As I anticipated, PCT has continued to make E-Tea available at a cost that is kind to consumer purse strings: http://www.teastohealth.com/skin.html

Sunny and his people have received many, many letters and statements from eczema patients, nurses and dermatologists down through the years attesting to E-Tea’s efficacy.

https://biotheorist.files.wordpress.com/2017/08/chinese-eczema-tea-version-2017.pdf

There are many more vexing medical challenges I have tackled down through the years (as a theorist) and a whole litany of them which has been placed on my plate by doctors, companies and even sufferers seeking answers that I am currently working on. And while I “live and move and have my being” for the most part in the Shadowlands you may come across my solutions down the line — albeit you likely will not know I am behind it.

© 2014 by Anthony G. Payne. All rights reserved.

Can an ancient Chinese herbal blend turn the tables on eczema?

By

Dr. Anthony G. Payne

HERB BLEND - FREE MSOne of the more rewarding aspects of natural products work is finding a viable treatment for a human malady; one which cannot be readily managed using standard pharmaceutical drugs. Thus was the case in 1990 with the discovery that a rather ancient Chinese traditional botanic formula produced noticeable improvement in atopic eczema in children. This observation was reported by J.I. Harper, MD, Department of Pediatric Dermatology, Hospital for Sick Children, London, England, in a letter published in the prestigious scientific journal, “The Lancet“. A list of ingredients employed in the Chinese tea was divulged, but not their proportions.

In 1993, a double-blind placebo-controlled clinical trial of the Chinese eczema tea and pediatric atopic eczema was performed by Dr. Harper and fellow researchers at the Hospital for Sick Children. Most of the children who drank the “real McCoy” (the experimental group) experienced a tremendous diminution of itching, pustules, and scales, for example, while those who sipped the placebo (the control group) did not significantly improve.

A subsequent one-year study was carried out, as described in this quote from a PubMed (medical database) abstract:

“The opportunity to continue treatment was offered to the parents of 37 children who had completed a double-blind placebo-controlled trial of a specific formulation of Chinese medicinal herbs for atopic eczema. The parents elected for continued treatment in every case, and the progress of the children was monitored over the following 12 months. The aim was to achieve a substantial clinical improvement, and thereafter to reduce treatment frequency progressively while maintaining this benefit.

“At the end of the year, 18 enjoyed at least 90 percent reductions in eczema activity scores, and five showed lesser degrees of improvement. Fourteen children withdrew from the study, 10 due to lack of response, and four because of unpalatability of treatment or difficulty in the preparation of treatment.

“By the end of the year, seven of the children were able to discontinue treatment without relapse. The other 16 required treatment to maintain control of their eczema, but only four of these still required daily treatment. Asymptomatic elevation of serum aspartate aminotransferase to 7-14 times normal values was noted on one occasion in two children whose eczema was so well controlled that the therapy was stopped. Liver function tests were normal 8 weeks later.

“We conclude that Chinese medicinal herbs provide a therapeutic option for children with extensive atopic eczema which has failed to respond to other treatments. In the medium term, it proved helpful for approximately half the children who originally took part in our placebo-controlled trial.” (Sheehan MP-Atherton DJ, “One-year follow up of children treated with Chinese medicinal herbs for atopic eczema,” Br J Dermatol, 1994 Apr, Volume: 130, pp. 488 through 493).

Again, the herbs in the eczema tea were disclosed but not the amounts of each. I decided to figure this out and as part of this recruited a large number of eczema patients – children, adolescents, and adults – mixed together the botanicals in varying proportions, and then gave out various versions. (Unlike the London study, however, I opted to use an encapsulated form as opposed to a foul-tasting tea).

It took over two years working at it part-time to arrive at the most effective combination for managing eczema, but effective it is! (My results paralleled those seen in the London-based clinical trials). And it’s not effective for eczema, but for other conditions in which certain species of free radicals and highly inflammatory substances called leukotrienes and prostaglandins play a role. The conditions which have shown a significant response to the eczema formula include asthma, emphysema, psoriasis, certain rheumatic conditions, and numerous neurological maladies.

One memorable and very telltale case involved a Vietnam veteran who presented with a rash and pustules over 90 percent of his body. The physicians at the V.A. center in Dallas were unable to effectively manage the condition, despite prescribing heavy doses of oral steroids coupled with liberal application of various topical drugs. I started this gentleman on one “eczema tea formula” capsule, 3 times each day for the first two weeks; then increased the dosage to two capsules 4 times daily. Within eight weeks of commencing the course of therapy, the rash and pustules had faded and essentially dried up. After another 3-4 weeks, he had virtually no visible evidence of what had been an almost three-decade nightmare.

One need only read about various skin conditions to realize the pervasiveness of this exasperating, debilitation dermatological challenge. For me, however, there is far more than a realization of how ubiquitous eczema is. As a boy I suffered from one of the worst cases of eczema imaginable. Even the steroid hormone, cortisone, didn’t help. Thankfully, my eczema went into permanent remission after age 5 or so, but I never forgot the more than three years I spent combating this nightmarish condition. And while it took me almost 36 years to turn my attention back to this human malady, the victory is no less sweet.

Nota bene: I turned over the Eczema or E-Tea formula to a company I was consulting for at the time, Prestige Chinese Teas, in 1993. I’d known and collaborated with PCT founder and President Sunny Wong since 1986 and knew he’d so all he could to get E-Tea into the hands of medical consumers at a cost they could afford, which he did. I did not ask for and ever received any proceeds from the sale of E-Tea (as I did not want to add to its cost by doing so) and ceased to be paid as a consultant for PCT in 1999 when I left the USA to teach in Japan. As I anticipated, PCT has continued to make E-Tea available at a cost that is kind to consumer purse strings: http://www.teastohealth.com/skin.html

 ©2014 by Dr. Anthony G. Payne. All rights reserved.

Reversing arterial blockage: Experimental regimen that worked for man facing amputation of his lower legs

Dr Payne at the Zeiss MicroscopeLast year (2012) I was contacted by a gentleman who had severe blockage in his legs and had been told by his physician-surgeon that he would need to amputate his legs below the knee. Naturally this chap was horrified at the prospect of living his life out of a wheelchair and/or on crutches and was frantic to know if there is anything, however experimental, that might help him avoid the surgeon’s knife. Apparently he had done a Google search and come across some of my health-related hypotheses (I have since 1986, been paid by various docs & researchers to spin hypotheses and provide novel ideas they could then pursue – or not).

I could not, of course, prescribe anything whatsoever as I am not a physician and lack the qualifications to get into such matters. However, what I did do is hand off an experimental regimen I originally developed in the late 1980s and had updated recently, along with the stringent caveat that much of my own work and that which informed it involved animal models of arterial blockage and I was giving him this with the strict understanding he would share it with his primary care MD and do what he said or advised.

I heard nothing from this chap for about 8 months and then got a call. It seems he was able to get his MD to endorse my handwork which he had followed religiously.  Long story short, the circulation in his legs had improved to the point that amputation was no longer on the proverbial table. Needless to say he and his wife of some 50+ years were overjoyed by his progress.

So here is what I shared with this guy – again, with the caveat it is experimental and unproved and should not be undertaken without the express consent & supervision of a duly licensed & practicing MD or DO.    

Dr. Anthony G. Payne

TO READ THE REST OF MY ARTICLE GO TO https://biotheorist.files.wordpress.com/2018/07/reversing-pad-cad-experimental-regimen-write-up-august-2013.pdf

PADMA: Scientifically validated Tibetan herbal blend

PADMA ARTICLE  COVER

Back in the 1980s I served as a scientific advisor to the firm (Berkley Wellness Network) that first brought the Tibetan vasocative product PADMA28 into the USA (BHN was bought by businessman Curtis Jaquot in the early 1990s and became “Pacific BioLogic, Inc.) In the mid-1990s I fed PADMA28 laced chow to guinea pigs with induced arterial blockage. Animals fed high doses showed a reversal of blockage.    

Note: I have no financial or other commercial interest in PADMA or any firm that makes, sells, markets, distributes or otherwise promotes it.

My 2007 article on PADMA 28:  https://biotheorist.files.wordpress.com/2018/07/padma-28-2017.pdf

PubMed search results: http://www.ncbi.nlm.nih.gov/pubmed/?term=PADMA+28

Is cooking the main culprit behind the arterial blockage seen in the Horus mummies study?

Assorted fruitDuring March of this year (2013) a paper appeared in the journal The Lancet titled “Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations”. You may have seen something about this among the many news articles and blurbs posted across the Web on the heels of this paper’s publication. If not, check out Science Daily’s excellent lay level piece on it at http://www.sciencedaily.com/releases/2013/03/130311091537.htm

 You can read the paper in its entirety at   http://download.thelancet.com/flatcontentassets/pdfs/S014067361360598X.pdf I perused it right after it came out and would like to share my thoughts on a possible culprit behind the arterial blockage that bedeviled the ancient peoples represented in the Horus study and which has cast a long shadow over modern populations as well (The fabled “Iceman“ Ötzi showed evidence of atherosclerosis too albeit he had a genetic predisposition and evidence of a chronic infection, namely borreliosis or Lyme disease).

CLICK THIS LINK TO READ THE REST OF THIS ARTICLE

 

 

HYPOTHESIS: Two ways in which cytomegalovirus carrying male germ cells may play a role in the genesis of autism spectrum disorder

Recently a paper was published showing that 33 of every 10,000 children born to older men (40 years of age or older) have autism spectrum disorder compared to 6 of every 10,000 children born to younger men (<30 years of age). Excerpts from a report in Nature News titled “Male biological clock possibly linked to autism, other disorders will help flesh this out:

“In a study of more than 100,000 people, along with records about their parents’ ages, Avi Reichenberg at King’s College London and his colleagues found that 33 out of every 10,000 offspring of men 40 years or older had autism spectrum disorder—a 475% increase compared to offspring of men younger than 30, who fathered afflicted children at a rate of 6 per 10,000 (Arch. Gen. Psychiatry 63, 1026–1032; 2006). This association is now being tested in a larger study, says Reichenberg. A study this September showed a similar but less pronounced association of parental age with bipolar disorder (Arch. Gen. Psychiatry 65, 1034–1040; 2008).

“Spontaneous mutations can arise in both sperm and eggs. As women age, for example, they have an increased risk of delivering a child with Down’s syndrome and other disorders caused by large-scale chromosome problems in eggs, such as trisomy. But unlike eggs, sperm arise from stem cells that continuously divide—about 840 times by the time a man is 50 years old (Cytogenet. Genome Res. 111, 213–228; 2005). The theory is that the chances of mutations increase with each round of DNA replication—a process that could underlie estimates that the mutation rate in males is about five times that in females (Nature 416, 624–626; 2002).

“Any mutation you can think of occurs more frequently in the sperm of older men,” says Sebat.

For a very long time it was thought mutations associated with the passage of time was something primarily peculiar to the ovum (A woman’s unfertilized egg). The belief that the genetic material in male sperm was somehow spared age-related mutations was driven home to me by a stem cell biologist I interacted with from 2008 to 2010, who was convinced that the male body had mechanisms in place that help insure that few if any mutations wound up in mature male sperm in healthy males regardless of age. This struck me as wishful thinking and I was quick to lock horns with this chap over this. Now comes tentative evidence – again, the results of the study just announced (above) – that would appear to vindicate my position. Although it is always fun to be right, I got to wondering what other players besides normal aging might be producing mutations in at least some men’s semen that set the stage in their progeny for the development of autism and other neurological conditions. The first thing that popped to mind was pathogenic microorganisms – especially viruses.  A quick check of published research brought up one particular bit of research that seemed to signal I was on the right track:   

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143078/pdf/2042-4280-2-7.pdf“Detection of human cytomegalovirus in motile spermatozoa and spermatogenic cells in testis organotypic culture”

 The long story short with respect to this study is that it found HCMV in male germ cells from semen samples (91 fertile and 47 infertile men) and in testis tissue culture.  There was a decrease in the number of immature germs cells that is believed attributable to the HCMV.  In short, the presence of the HCMC in a man’s reproductive tract – and, mind you, 50-80 of every 100 Americans harbor the HCMV according to the CDC – tosses a monkey-wrench in the genetic apparatus of sperm resulting in infertility.  There are undoubtedly other viruses that populate the male reproductive system including others of the herpes family that may well have a similar effect.

What if the genetic changes go beyond infertility? What if HCMV produces genetic mutations in fertile men’s sperm? Some of these, I conjecture, could set the stage for producing autism in children they father.

Now – and here is where my off-the-cuff theorizing gets really interesting – what would happen if a HCMV-infected spermatozoon fertilizes a female ovum? In some instances it becomes activated and effects varying damage to one or more developing fetal tissues/organs including the brain and even generates defects severe enough to result in miscarriage. However, what I propose is that most HCMV transmitted to a fetus at conception by an infected male germ cell (sperm) is latent (inactive)and winds up in various tissues though primarily the CNS [The virus preferentially infects neurons probably brain stem & progenitor cells too (This is the case in mouse models of CMV infection)].  Though not active in the sense it produces clinical symptoms it could conceivably cause subtle neurologic changes and damage that is later manifest as autism spectrum disorder (One murine study notes: “Infection of neurons may tend to become persistent by evasion of immune reactions, anti-apoptotic effects and neuron-specific activation of the e1-promoter, presumably causing functional neuronal disorders. It has also been shown that CMV infection in developing brains may become latent in neural immature cells”. These effects were observed in active infections. However, it may affect subtle genetic damage in neurons in a child’s developing brain though the virus is latent or largely inactive).

This body of conjecture is testable. And, if it turns out HCMV is damaging some men’s germ cell DNA in ways that set the stage for autism (and possibly other neurologic disorders) in children they father and/or the virus is being passed on to zygote (by the male gamete) and ultimately the embryo’s developing CNS where it sets the stage for the development of autism or other neurologic disorders years after birth, testing for the HCMV’s presence in semen and (when determined to be present)  interfering with the HCMV in the man’s reproductive tissues by treating with extant antiviral drugs are measures that might reduce the likelihood the virus will wreck biologic havoc either in the developing embryo or later in the developing baby or child.

I hope some enterprising grad student or researcher transforms my ruminations into suitable bench experiments and runs with it.       

Additional Reading: This paper titled “Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention delves deeply into technical issues I only touched on above as well as prevention and treatment aspects of HCMV infections.

 © 2012 by Dr. Anthony G. Payne. All rights reserved. If you are a grad student or researcher who runs with one or both of the ideas articulated above, please let me know what you do and the outcome: attachi-mailbox at yahoo.com

You can access this hypothesis as a PDF document by clicking this link:  http://www.healingcare4u.org/articles/HYPOTHESIS%20-%20HCMV%20and%20autism%20-%209-9-2012.pdf

Eradicating cancer: Metabolic monkey wrenching including use of autophagy inhibitors

On 9-6-2012 ScienceDaily ran this article:  http://www.sciencedaily.com/releases/2012/09/120906074249.htmAcidic Microenvironments in Tumors Aid Tumor Cell Survival, Researchers Find

Here is a link to the full paper(Cancer Res 2012;72:3938-3947. Published Online First June 19, 2012) for those interested in perusing this: http://cancerres.aacrjournals.org/content/72/16/3938.full.pdf+html  – Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

Interestingly, my Metabolic Oncolytic Regimen (original body of theory – 1990 — various permutations since) is based on lowering pH in hypoxic regions of solid tumors to lethal levels: http://www.healingcare4u.org/The%20Metabolic%20Oncolytic%20Regimen%20(Revised%202011).pdf

However, as the paper in the Cancer Research Journal (link above) signals, tumor cells in acidic regions adapt and survive by chronically activating autophagy pathways. Thankfully though, this can be circumvented by use of autophagy inhibitors:   

http://www.landesbioscience.com/journals/autophagy/BenSahraAUTO6-5.pdfThe combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

http://www.jbc.org/content/281/46/34870.full.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557039/

http://www.sigmaaldrich.com/life-science/cell-biology/cell-biology-products.html?TablePage=104899425List of Autophagy inhibitors (Sigma Chemical) including N-acetyl-cysteine

http://www.tocris.com/pharmacologicalBrowser.php?ItemId=296970&Type=Inhibitors Autophagy Inhibitors – Tocris Bioscience

Hydroxychloroquine and chloroquine are autophagy inhibitors.

http://www.nature.com/nbt/journal/v30/n7/fig_tab/nbt.2285_T2.htmlTable 2: Autophagy inducers and inhibitors for cancer treatment

This line of work & reasoning suggests that a marriage of the MOR (or a similar “metabolic anti-tumor monkey wrenching” approach) with one or more autophagy inhibitors should deliver a death blow to at least some solid tumors. 

 

 

 

HARM: A compendium

HARM: A compendium of statistics & information  (Harm done by conventional health care v. AltMed practices & supplements)     
 
Web address: http://bit.ly/N5xk3t 

Amyotrophic Lateral Sclerosis (ALS): Stimulating Proteasome Activity in Motor Neurons to accelerate degradation of misfolded proteins

https://biotheorist.files.wordpress.com/2018/07/als-stimulating-proteasome-activity-in-motor-neurons.pdf Nota bene: Three (3) people with ALS who began using this regimen on their own have reported experiencing significant weight and energy gains plus enhanced muscle strength. All 3 have been on this regimen for more than 5 months as of 3-26-12.
Regimen subsequently improved with users reporting additional gains. 
COMPLEMENTS: http://www.sciencedirect.com/science/article/pii/S030698770900022X

How one man turned adversity into opportunity

Jim Haverlock has seen more peaks & valleys than most of us. Athlete in HS and now scooter-bound due to multiple sclerosis. Millionaire owner of a furniture chain who went broke, worked out of his car for a time,  and now runs his own virtual business and provides web building & optimization services too. Abandoned by his wife after he was misdiagnosed as having ALS (Lou Gehrig’s disease) — but now (in his seventies) sharing love & life with his “African Queen.”  Dreamed of being a missionary as a young man — tabled this — and fulfilled this calling more than five (5) decades later by founding a nonprofit charitable organization called Compassion Care! If this has you wanting to know more about “The Life & Times of Missionary Jim” — just click this link:  

https://biotheorist.files.wordpress.com/2011/07/jims-story-heart-of-a-missionary-edited-spin-july-15-20113.pdf

Reading Room: Ketogenic Diet, Reducing Calcium in Arteries, Prostate Massage

LINKS TO LIVESTRONG.COM ARTICLES

CAM (Complimentary & Alternative Medicine)

 “Low Carb Ketogenic Diet” (LiveStrong.com)

“How to Reduce Calcium in Arteries” (LiveStrong.com)

CARDIOVASCULAR

 “How to Reduce Calcium in Arteries” (LiveStrong.com)

 DIET

 “Low Carb Ketogenic Diet” (LiveStrong.com)

PREVENTION

 “Low Carb Ketogenic Diet” (LiveStrong.com)

“How to Reduce Calcium in Arteries” (LiveStrong.com)

“Prostate Massage Methods” (LiveStrong.com)

 SEXUAL ISSUES

“Prostate Massage Methods” (LiveStrong.com)

 

 

Through the CAM looking Glass

Looking glass worldshttps://biotheorist.files.wordpress.com/2018/07/natural-medicine-a-cautionary-look.pdf

Study reveals that masturbation reduces odds of developing prostate cancer

There have been a number of studies that suggest that regular masturbation by men, especially during their youth to perhaps age 50, flushes carcinogens that tend to accumulate in the prostate from the gland and by so doing help prevent initiation of cancer in this gland. One recent one was carried out by the Council of Victoria which revealed that men who masturbate to ejaculation more than five times per week were one-third less likely to develop prostate cancer.

If this correlation is true, it logically follows that the greater the degree of prostate “emptying” the more likely a man is to purge his prostate of cancer-causing compounds and thus the lower his risk of developing carcinoma of the prostate. There are a number of ways to (ahem) pull this off:

(1) Prostate massage: This commercial website appears to provide some really sound advice in this regard. Note that I have no financial or other interest in this website of any firm it links to or promotes.

(2) Masturbate while using the a prostate electrostimulation device. These provide users with what amounts to a gentle though powerful pulsating “electric massage” of the prostate which is highly stimulating and pleasurable. Many men report having more copious ejaculations when they climax while using this type of gadget (Which is the goal when it comes to draining the prostate of fluids that might harbor carcinogenic substances). It is also reputed to jump-start the erection machinery in the male body which leads to firmer, stronger erections.

(3) Use the Aneros prostate massager or something similar during masturbatory sessions .

Also check out: OSTEOPOROSIS IN WOMEN: SEMINAL FLUID COMPOUNDS ABSORBED THROUGH MUCOSAL TISSUES HELP PROTECT AGAINST & REMEDIATE BONE LOSS   (Idea/hypothesis) by Dr. Payne.

Disclaimer: Dr. Payne has no financial or other commercial interest in any device or firm marketing same mentioned in this article. 

The information contained in this article is provided for informational purposes only and should not be construed as medical advice or instruction. Readers are advised to consult a licensed health care professional concerning all matters related to their health and well being.

© 2011 by Dr. Anthony G. Payne. All rights reserved.

Preventing & Reversing Cataracts

envious eye

Down through the years I have collected information and data that indicates that immature cataracts can be gradually, effectively shrunk (and even obliterated) when two natural OTC products are judiciously taken over a 6-18 month period of time:

  1. N-acetyl-carnosine eye drops.
  2. Rehmannia Eight Formula (Traditional Chinese herbal drug)  

Here are links to two abstracts concerning N-A-Carnosine on PubMed: 

 N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications.

Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats.

And with regard to the CTM Herbal Phytodrug:

http://ecam.oxfordjournals.org/cgi/reprint/1/3/269

A CASE OF SUCCESSFUL CATARACT TREATMENT IN A DIABETIC WOMAN

In an article from Japan , published in the American Journal of Chinese Medicine (5), three physicians report on a successful case of cataract treatment with a traditional herb formula. This involved a 68-year-old woman with diabetes having a cataract in one eye. The cataract had been present for more than four years at the time of treatment with the herb formula. She was given Achyranthes, Plantago, and Rehmannia Formula. She had been taking Catalin eye drops and Tathion eye drops (glutathione eye drops, another antioxidant strategy), with only slight effect, but when she began taking the herb formula, her vision began to rapidly improve within 10 days, and continued to improve over three months of therapy. The affected eye then remained in improved condition thereafter, with continued use of the herbs (dried extract granules, 7.5 grams per day).

Here is one source for the Rehmannia Eight Formula: 

http://eastearthtrade.com/index.asp?PageAction=VIEWPROD&ProdID=114 à Rehmannia Eight Formula (Chinese: Ba Wei Di Huang Wan, Japanese: Hachimi-jio-gan) is the most popular herbal treatment in Japan for diabetes. The formula aids insulin regulation and halts the progression of diabetic nerve damage and prevents eye and circulation problems1. May also help with memory loss. Research has also shown it helps delay the formation of cataracts. Use 2-4 capsules three times per day.

Contains: Rehmannia, Cornus, Chinese Yam (Dioscorea), Hoelen (Poria), Alisma, Aconitum, Cinnamon twig, Moutan.

Size: 100 capsules

NOTE:  I have no commercial, financial or other ties to the aforementioned companies or products.

 © 2009 by Dr. Anthony G. Payne. All rights reserved.

The information contained in this article is provided for informational purposes only and should not be construed as medical advice or instruction. Readers are advised to consult a licensed health care professional concerning all matters related to their health and well being.

Experimental regimen targeting the ependyma slows disease progression in four patitents with ALS

 

Citation: Payne AG. ,’Experimental regimen targeting the ependyma slows disease progression in four patitents with ALS,’ Med Hypotheses (2009), doi:10.1016/j.mehy.2008.12.032 

Experimental regimen targeting the ependyma slows disease progression in four patients with amyotrophic lateral sclerosis

Dr. Anthony G. Payne*

E-mail: DrAGPayne@yahoo.com

SUMMARY

 In this paper the author proposes that at least some forms of sporadic ALS (amyotrophic lateral sclerosis) arise due to the effects of neurotoxic compounds synthesized by defective ependymal cells in the brain. These cells produce cerebrospinal fluid (CSF) that is laden with neurotoxic compounds that bring about motor neuron die-off. Evidence is garnered from various animal studies to demonstrate the toxicity of CSF taken from ALS patients and by virtue of the proposed mechanism (defective ependymal cells). In addition, a regimen created by the author is introduced; a regimen that has been used by four (4) sporadic ALS patients since 2005 resulting in what appears to be a slowing of disease progression. All four patients have significantly outlived best estimates of their survival tendered by their neurologists. 2009 Published by Elsevier Ltd.

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