I have worked with a coenzyme called pyrroloquinoline quinone (PQQ) for quite a while now and think it is worth a “look see” by physicians and others for its preventative and therapeutic potential. Let’s dive into this now:
First, let’s “do the time warp, now”: During 1994-5 I worked in an Ag lab and large greenhouse complex outside Lincoln, Nebraska (Which was devoted to the testing of various nature-derived growth accelerants on culinary & medicinal mushrooms). One of the principle consulting researchers who rubbed elbows with me was Andy Anderson, PhD, who discovered a radioresistant bacterium back in 1956 while irradiating food at the Oregon Agricultural Experimental Station in Corvallis (As I recall from our chitchat, he was irradiating canned foods to see if this would reliably preserve them against spoilage). The bacterium was subsequently dubbed Deinococcus radiodurans and is indisputably the most radioresistant organism discovered to-date.
Anyway, while kibitzing with Dr. Anderson we discussed possible mechanisms by which Deinococcus radiodurans was able to escape destruction by intense gamma ray exposure. One of things we tossed about as a putative key player was, yes, pyrroloquinoline quinone (PQQ). There was, in fact, things pointing to this that went back in the literature to the 1960s (PQQ was discovered in 1964, as I recall).
Now, fast forward to modern times: Doctors, patients, consumer advocates and others are mindful that x-rays, SPECT scans, and other screening scans that involve radiation can have deleterious “downstream” effects — which got me to thinking about Dr. Anderson and our chat about pyrroloquinoline quinone (PQQ). Mind you, I’ve shared information on use of purified PQQ with physicians and others as a promising preventative/remediative measure with respect certain cardiovascular and neurologic conditions and insults for many years now (In part due to its ability to stimulate mitochondriogenesis). Granted, it is poorly assimilated in the gut but thankfully works at low levels and is, in fact, recycled many times over in vivo. But I hadn’t thought about PQQ as a possible radioprotective compound since 1994 and my days in “The little lab on the prairie”.
With that old chat-fest with Dr. Anderson in mind I shot over to PubMed and did a search to see if any contemporary studies had been done that linked PQQ to radioprotection. And, bingo, I struck pay dirt —
|Pyrroloquinoline quinone and a quinoprotein kinase support γ-radiation resistance in Deinococcus radiodurans and regulate gene expression.|
|Rajpurohit YS, Desai SS, Misra HS.|
|J Basic Microbiol. 2013 Jun;53(6):518-31. doi: 10.1002/jobm.201100650. Epub 2012 Sep 7.|
|Production and radioprotective effects of pyrroloquinoline quinone. (Mouse study)|
|Xiong XH, Zhao Y, Ge X, Yuan SJ, Wang JH, Zhi JJ, Yang YX, Du BH, Guo WJ, Wang SS, Yang DX, Zhang WC.|
|Int J Mol Sci. 2011;12(12):8913-23. doi: 10.3390/ijms12128913. Epub 2011 Dec 5.|
In light of the animal study especially, it follows that PQQ given well before & following an x-rays, SPECT scans & the like could (should?) afford radioprotection of those neural & other tissues it cycles through.
Now, this isn’t all there is to PQQ. While visiting with a physical anthropologist we got into discussing one of my favorite hominins (australopithecines), Paranthropus boisei (Also referred to as Australopithecus boisei) who is popularly referred to as “Nutcracker Man”. I knew from various recent papers & popular articles that Paranthropus boisei thrived on a tuber known as “tiger nuts”. See this article: http://www.sci-news.com/othersciences/anthropology/science-paranthropus-boisei-tiger-nut-diet-01680.html
Anyway, with PQQ on my mind I asked this anthropologist if she knew whether “tiger nuts” are rich in this coenzyme. She didn’t know so we did a literature search and found that PQQ tends to occur in very high amounts in tubers!
While it will take gas chromatograph testing to determine the exact PQQ content in tiger nuts, I think the fact they helped nourish & sustain such a robust hominin as Paranthropus boisei suggests they may also be worth consuming on the part of physically active folks (Athletes especially) as well as those predisposed to developing certain neurologic or cardiovascular diseases and conditions. I then did some on-line digging and came up with a US based firm that markets tiger nuts and has posted this tuber’s impressive nutritional profile: https://tigernutsusa.com/ ( Note Bene: I have no commercial or other interest in this firm or any other that grows, harvests, sells, markets, or processes PQQ or tiger nuts).
So, all told, I think there is (ahem) “food for thought” in all this with respect to the possible use of PQQ by radiologists, dentists and other health care professionals in patients of theirs doing radiation-based scans (pre & post exposure measure), and also for the inclusion of tiger nuts in various diet plans and programs.
Go to http://www.scribd.com/doc/223658050/PQQ-Nutcracker-Man-Tiger-Nuts-Radiation-protection-heart-nervous-system-benefits where you’ll find 52 citations from PubMed on PPQ. Among these you will find published papers suggesting PQQ might prevent and/or remediate Alzheimer’s disease related processes, neural damage due to methylmercury exposure, TBIs, and much more in patients (Granted, many of these studies involved cell culture work but there are also those involving animal models and a few, humans).
Choctaw Doc (Anthony G. Payne)
REVIEW ARTICLE ON PQQ & HEALTH:
REVIEW ARTICLE ON PQQ IN VARIOUS BIOLOGIC PROCESSES: