COVID-19: food compounds that inhibit a key enzyme in SARS-CoV-2 gene expression and replication

Dec 1

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Chemical compounds in foods can inhibit a key SARS-CoV-2 enzyme (phys.org)

Link to the full paper: Frontiers | Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2 | Plant Science (frontiersin.org)

Although the study covered in the paper (link above) involved a combination of computer simulation & benchtop experiments, I know from decades of interaction with medical information & product consumers that some of you reading this will want to know “the bottom-line” — mainly so you can go out and buy the foods and/or food concentrates or extracts in question. OK then, here it is:

Most effective in inhibiting the SAR-Co-2 (Covid-19) Mpro enzyme activity were certain green tea compounds such as EGCG and extracts from two muscadine grape cultivars (grapes + skin & seeds).

Cocoa and raw chocolate compounds were the “runners up”.

From the paper: “Conclusion, both docking simulation and in vitro assay showed that (–)-catechin-3-O-gallate (7), (–)-epicatechin-3-O-gallate (8), (–)-gallocatechin-3-O-gallate (9), and (–)-epigallocatechin-3-O-gallate (10), procyanidin B1 (11) and B2 (12) inhibited the Mpro activity of SARS-Cov-2. Moreover, these compound-rich extracts of green tea, muscadine grape, cacao, and dark chocolate also inhibited the Mpro activity.”

Green tea, muscadine, cacao and raw chocolate extracts, concentrates and such are sold all across cyber-land. Here are a few for you to check out (Note that I have no commercial, financial or other vested interest in these products):

Green tea extract capsules:

Vitacost Green Tea Extract – Standardized — 500 mg – 100 Capsules – Vitacost

Zhou Green Tea Extract 500 mg 120 Veg Caps – Swanson Health Products (swansonvitamins.com)

Epigallocatechin gallate (ECGC) capsules:

NOW Foods EGCg Green Tea Extract 400 mg 180 Veg Caps – Swanson Health Products (swansonvitamins.com)

Amazon.com: NOW Supplements, EGCg Green Tea Extract 400 mg, Free Radical Scavenger*, 180 Veg Capsules: Health & Personal Care

Amazon.com: EGCG Green Tea Extract Pills | 1200 mg 180 Capsules | Max Potency | Non-GMO & Gluten Free Supplement | by Horbaach: Health & Personal Care

Muscadine grape products

Vitacost Muscadine Grape Seed — 500 mg – 120 Capsules – Vitacost

VineLife Muscadine Grape Seed & Skin 650mg – 60 Veggie … (searchwellness.com)

Amazon.com : muscadine

Cacao & dark chocolate

Swanson Premium Full Spectrum Cacao (Raw Cocoa) 400 mg 60 Caps – Swanson Health Products (swansonvitamins.com)

VitaDigest.com Offer – Earth Circle Organics, Organic Raw 70% Dark Chocolate, 8.8 oz (250 g)

Click to access cacao powder search results on Google

About Dr. Anthony G. Payne

Most of the time you will find me spinning ideas and web content for client firms and especially physicians (MDs and DOs). Among my many passions are helping others help others, word weaving (Published writer & author, ghostwriter, copywriter, proofreader, editor), and art (Mainly sketching. I revel in Jackson Pollock's art and thus enjoy experimenting with his approach combined with those of other artists). Nature is a focus too, reflected in the fact I have been involved in the deep ecology movement since the 1980s and (more recently) the Forest Church movement. I am also a lay Celtic Christian monk (Novice monk in 2015, full monk in 2017). This is the realization of a calling I have "flirted with" for many moons now. You are encouraged to check out my "Summer Cloud's Spiritual Watering Hole"​ website to learn more: http://summerclouds.weebly.com.

Posted on December 1, 2020, in ANTIVIRUS PROJECT, CAM - Complementary Alternative Medicine, CORONAVIRUS (COVID-19), EGO write proinde EGO sum, HERBAL MEDICINE, MEDICINE, MINISTRY OF ENLIGHTENMENT, NUTRITION & DIET, Nutrition Science, VIRAL DISEASES (Contagious) and tagged , , , , , . Bookmark the permalink. Comments Off on COVID-19: food compounds that inhibit a key enzyme in SARS-CoV-2 gene expression and replication.

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