Monthly Archives: November 2012
Nota bene: Much of my work down through the years could not be published anywhere as it would compromise proprietary use by those I worked for/with.
Med Hypotheses. 2007;68(4):828-31. Epub 2006 Oct 19.
Exploiting hypoxia in solid tumors to achieve oncolysis.
Chemo- and radio-resistant cancer cells within solid tumors undermine the effectiveness of these approaches to achieving oncolysis. These resistant cells and clusters of cells typically thrive at low oxygen tensions and are reliant on anaerobic metabolic pathways that churn out lactate. This hypoxic state is one that can be exploited and in this paper a novel method is advanced involving tumor cell infiltration by bifidobacterium species which should bring about prodigious lactate synthesis; concomitant blocking of its enzymatic degradation by urea as well as export (from the cell) by use of quercetin; depletion of ATP using exogenous thyroid; and compromised oxidative catabolism of free fatty acids and amino acids via oral intake of l-hydroxycitrate, melatonin and nontoxic NDGA. This “anaerobic pathway cocktail”, it is hypothesized, will bring about a profound reduction in intracellular pH and a compromised state of cellular energetics sufficient to effect oncolysis.
Med Hypotheses. 2005;64(4):880-1.
Ciliary neurotrophic factor: its possible role as a stem cell homing beacon in neurological diseases and disorders.
Med Hypotheses. 2004;62(5):718-20.
Using immunomagnetic technology and other means to facilitate stem cell homing.
If stem cell therapy is to be maximally effective, it is vital that progenitor (stem) cells get to the target tissue(s) and/or organ(s). Three methods of facilitating stem cell homing to target tissues are explored in this paper: (1) cobalt compounds such as cobalt phthalocyanines could be magnetically delivered to target tissue(s) and/or organ(s), and then subject to a brief pulsed magnetic field or ultrasound exposure suitable to induce mild hyperthermia with the result being the synthesis of cytokines that are chemoattractants to progenitor (stem) cells; (2) ferromagnetic nanobead particles could be tagged with antibodies specific to the target tissue(s) and/or organ(s) and infused into patients, followed by introduction of progenitor (stem) cells tagged with antibody-bound magnetic nanoparticles. This should result in passive attachment (stem cells to tagged tissue or organ); and (3) Reticulose, which stimulates the synthesis of the stem cell chemoattractant IL-8, could be magnetically guided to target tissue(s) and/or organ(s).
Med Hypotheses. 2009 May;72(5):548-50. Epub 2009 Feb 5.
Experimental regimen targeting the ependyma slows disease progression in four patients with amyotrophic lateral sclerosis.
In this paper the author proposes that at least some forms of sporadic ALS (amyotrophic lateral sclerosis) arise due to the effects of neurotoxic compounds synthesized by defective ependymal cells in the brain. These cells produce cerebrospinal fluid (CSF) that is laden with neurotoxic compounds that bring about motor neuron die-off. Evidence is garnered from various animal studies to demonstrate the toxicity of CSF taken from ALS patients and by virtue of the proposed mechanism (defective ependymal cells). In addition, a regimen created by the author is introduced; a regimen that has been used by four (4) sporadic ALS patients since 2005 resulting in what appears to be a slowing of disease progression. All four patients have significantly outlived best estimates of their survival tendered by their neurologists.
Science. 2005 Jan 14;307(5707):208-9; author reply 208-9.
Inflammation and life-span.
Inflammatory exposure and historical changes in human life-spans.Finch CE, Crimmins EM. Science. 2004 Sep 17; 305(5691):1736-9.
 Anthony G. Payne*  Beneficial Effects of Subcutaneously Injected
Human Umbilical Cord Stem Cells on Cerebral Palsy and Traumatic Brain Injury in Children and a Posited Mechanism. pp. 497 – 501.
 Anthony G. Payne*  Preventing Metastasis and Achieving Oncolysis in
Solid Tumors by Inhibiting Specific Metalloproteinases and Manipulating Key
Metabolic Pathways. pp. 553-565.
 Fernando Ramirez, David A. Steenblock, Anthony G. Payne* and Lyn Darnall  Umbilical Cord Stem Cell Therapy for Cerebral Palsy. pp. 679-686.