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Ependyma & CSF & stem cells & ALS: Connect the dots

mri-of-brain-free-msPublic Release: 21-Jul-2016

►►MY MOST POPULAR BLOG ENTRIES (CATEGORIZED)

Confident BusinessmanCANCER, ALS, REVERSING ARTERIAL BLOCKAGE

Killing cancer, sparing the patient (Targeting tumor cells while leaving normal ones unaffected)

Looking for treatment options for ALS, heart disease, cancer or eczema?

Reversing arterial blockage: Experimental regimen that worked for man facing amputation of his lower legs

 

GIVE ME THAT OLD TIME…THEORY

Is cooking the main culprit behind the arterial blockage seen in the Horus mummies study?

Getting stem cells to target using magnetic means

Papers by Choctaw Doc

HYPOTHESIS: Two ways in which cytomegalovirus carrying male germ cells may play a role in the genesis of autism spectrum disorder

Amyotrophic Lateral Sclerosis (ALS): Stimulating Proteasome Activity in Motor Neurons to accelerate degradation of misfolded proteins

 

A SPOONFUL OF NATURAL MEDICINE

Of PQQ, Nutcracker Man & Tiger Nuts (PQQ as radioprotective with heart & nervous system benefits)

Can an ancient Chinese herbal blend turn the tables on eczema?

PADMA: Scientifically validated Tibetan herbal blend

 

SPIRTUALITY

More spiritual than religious? Perhaps a messianic God-fearer?

From the “sure to throw off your spiritual gyroscope” department: 3 books — 2 free online & 1 cheap through Amazon

Is global upheaval knocking at the door? (Red moons, ancient prophecies, and more)

The Spiritual Aspect of Holistic Medicine

Did the Almighty send an emissary to the ancient Cahokian (American Indian) people?

The dog you feed the most will dominate your life

Alienation: Pervasive and insidious

 

THOSE WHO DO NOT LEARN FROM LIFE & HISTORY ARE…..(YOU KNOW)

What to do with militant extremists in our midst? It’s a question Americans have faced before

How do you kill 12 million people? Evil then and now: Recognizing & containing it

Dark times and the allure of evil solutions

 

SEX GONE WRONG

Sexless relationships: What accounts for this reverse alchemy (Gold to lead)?

Sexting, Sex Tapes & Sexual Exhibitionism: Why have so many folks thrown caution to the wind?

 

BOOKS WORTH BORROWING, BUYING OR (AHEM) PILFERING

Mind Expansion: Recommending Reading (Books, books & more books)

 

 

Of PQQ, Nutcracker Man & Tiger Nuts (PQQ as radioprotective with heart & nervous system benefits)

Pyrroloquinoline quinone - Wikpedia

Pyrroloquinoline quinone – Wikpedia

I have worked with a coenzyme called pyrroloquinoline quinone (PQQ) for quite a while now and think it is worth a “look see” by physicians and others for its preventative and therapeutic potential. Let’s dive into this now:

First, let’s “do the time warp, now”: During 1994-5 I worked in an Ag lab and large greenhouse complex outside Lincoln, Nebraska (Which was devoted to the testing of various nature-derived growth accelerants on culinary & medicinal mushrooms). One of the principle consulting researchers who rubbed elbows with me was Andy Anderson, PhD, who discovered a radioresistant bacterium back in 1956 while irradiating food at the Oregon Agricultural Experimental Station in Corvallis (As I recall from our chitchat, he was irradiating canned foods to see if this would reliably preserve them against spoilage). The bacterium was subsequently dubbed Deinococcus radiodurans and is indisputably the most radioresistant organism discovered to-date.

Anyway, while kibitzing with Dr. Anderson we discussed possible mechanisms by which Deinococcus radiodurans was able to escape destruction by intense gamma ray exposure. One of things we tossed about as a putative key player was, yes, pyrroloquinoline quinone (PQQ). There was, in fact, things pointing to this that went back in the literature to the 1960s (PQQ was discovered in 1964, as I recall).

Now, fast forward to modern times: Doctors, patients, consumer advocates and others are mindful that x-rays, SPECT scans, and other screening scans that involve radiation can have deleterious “downstream” effects — which got me to thinking about Dr. Anderson and our chat about pyrroloquinoline quinone (PQQ). Mind you, I’ve shared information on use of purified PQQ with physicians and others as a promising preventative/remediative measure with respect certain cardiovascular and neurologic conditions and insults for many years now (In part due to its ability to stimulate mitochondriogenesis). Granted, it is poorly assimilated in the gut but thankfully works at low levels and is, in fact, recycled many times over in vivo. But I hadn’t thought about PQQ as a possible radioprotective compound since 1994 and my days in “The little lab on the prairie”.

With that old chat-fest with Dr. Anderson in mind I shot over to PubMed and did a search to see if any contemporary studies had been done that linked PQQ to radioprotection. And, bingo, I struck pay dirt —

Pyrroloquinoline quinone and a quinoprotein kinase support γ-radiation resistance in Deinococcus radiodurans and regulate gene expression.
Rajpurohit YS, Desai SS, Misra HS.
J Basic Microbiol. 2013 Jun;53(6):518-31. doi: 10.1002/jobm.201100650. Epub 2012 Sep 7.
  Production and radioprotective effects of pyrroloquinoline quinone. (Mouse study)
Xiong XH, Zhao Y, Ge X, Yuan SJ, Wang JH, Zhi JJ, Yang YX, Du BH, Guo WJ, Wang SS, Yang DX, Zhang WC.
Int J Mol Sci. 2011;12(12):8913-23. doi: 10.3390/ijms12128913. Epub 2011 Dec 5.
PMID: 22272111

COMPLETE PAPER: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257108/pdf/ijms-12-08913.pdf        

In light of the animal study especially, it follows that PQQ given well before & following an x-rays, SPECT scans & the like could (should?) afford radioprotection of those neural & other tissues it cycles through.

Paranthropus boisei (Nutcracker Man) - Wikipedia Commons

Paranthropus boisei (Nutcracker Man) – Wikipedia Commons

Now, this isn’t all there is to PQQ. While visiting with a physical anthropologist we got into discussing one of my favorite hominins (australopithecines), Paranthropus boisei (Also referred to as Australopithecus boisei) who is popularly referred to as “Nutcracker Man”. I knew from various recent papers & popular articles that Paranthropus boisei thrived on a tuber known as “tiger nuts”. See this article: http://www.sci-news.com/othersciences/anthropology/science-paranthropus-boisei-tiger-nut-diet-01680.html

And this paper: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084942

Anyway, with PQQ on my mind I asked this anthropologist if she knew whether “tiger nuts” are rich in this coenzyme. She didn’t know so we did a literature search and found that PQQ tends to occur in very high amounts in tubers!

While it will take gas chromatograph testing to determine the exact PQQ content in tiger nuts, I think the fact they helped nourish & sustain such a robust hominin as Paranthropus boisei suggests they may also be worth consuming on the part of physically active folks (Athletes especially) as well as those predisposed to developing certain neurologic or cardiovascular diseases and conditions. I then did some on-line digging and came up with a US based firm that markets tiger nuts and has posted this tuber’s impressive nutritional profile: https://tigernutsusa.com/ ( Note Bene: I have no commercial or other interest in this firm or any other that grows, harvests, sells, markets, or processes PQQ or tiger nuts).

So, all told, I think there is (ahem) “food for thought” in all this with respect to the possible use of PQQ by radiologists, dentists and other health care professionals in patients of theirs doing radiation-based scans (pre & post exposure measure), and also for the inclusion of tiger nuts in various diet plans and programs.

Go to http://www.scribd.com/doc/223658050/PQQ-Nutcracker-Man-Tiger-Nuts-Radiation-protection-heart-nervous-system-benefits where you’ll find 52 citations from PubMed on PPQ.  Among these you will find published papers suggesting PQQ might prevent and/or remediate Alzheimer’s disease related processes, neural damage due to methylmercury exposure, TBIs, and much more in patients (Granted, many of these studies involved cell culture work but there are also those involving animal models and a few, humans).

Choctaw Doc (Anthony G. Payne)

REVIEW ARTICLE ON PQQ & HEALTH:

http://www.altmedrev.com/publications/14/3/268.pdf

REVIEW ARTICLE ON PQQ IN VARIOUS BIOLOGIC PROCESSES:

http://www.ias.ac.in/jbiosci/jun2012/313.pdf

A little YouTube fun along the way

CHOCTAW DOC SHOW“THE CHOCTAW DOC SHOW” (7M:21S YOUTUBE VIDEO): http://www.youtube.com/watch?v=mSsHJWvYbLo&feature=youtu.be

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ALTERNATIVES & OPTIONS (SHORT VIDEO BY CHOCTAW DOC): https://www.youtube.com/watch?v=9tR6iAHCcrc

Links to Choctaw Doc’s main web & blog sites (Free information & articles galore)

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CHOCTAW DOC ON ABOUT.ME: http://about.me/ChoctawDoc

ALTERNATIVES & OPTIONS (SHORT VIDEO BY CHOCTAW DOC): https://www.youtube.com/watch?v=9tR6iAHCcrc

“THE CHOCTAW DOC SHOW” (7M:15S YOUTUBE VIDEO): http://www.youtube.com/watch?v=1VVBKk-venc&feature=youtu.be

 

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Amyotrophic Lateral Sclerosis (ALS): Stimulating Proteasome Activity in Motor Neurons to accelerate degradation of misfolded proteins

http://bit.ly/wcr7bP  Nota bene: Three (3) people with ALS who began using this regimen on their own have reported experiencing significant weight and energy gains plus enhanced muscle strength. All 3 have been on this regimen for more than 5 months as of 3-26-12.

Regimen subsequently improved with users reporting additional gains. 

COMPLEMENTS: http://www.sciencedirect.com/science/article/pii/S030698770900022X

ALSO: Messed up cellular “garbage disposal system” found to play a role in Alzheimer’s disease (And Nova Cell’s BEACON FACTOR coaxes lysosomes to do their job!)

How one man turned adversity into opportunity

Jim Haverlock has seen more peaks & valleys than most of us. Athlete in HS and now scooter-bound due to multiple sclerosis. Millionaire owner of a furniture chain who went broke, worked out of his car for a time,  and now runs his own virtual business and provides web building & optimization services too. Abandoned by his wife after he was misdiagnosed as having ALS (Lou Gehrig’s disease) — but now (in his seventies) sharing love & life with his “African Queen.”  Dreamed of being a missionary as a young man — tabled this — and fulfilled this calling more than five (5) decades later by founding a nonprofit charitable organization called Compassion Care! If this has you wanting to know more about “The Life & Times of Missionary Jim” — just click this link:  

https://biotheorist.files.wordpress.com/2011/07/jims-story-heart-of-a-missionary-edited-spin-july-15-20113.pdf

 

EXAMINER ARTICLES by Choctaw Doc: CAM, Diet, Prevention, Sex

LINKS TO EXAMINER ARTICLES

CAM (Complimentary & Alternative Medicine)

All that glitters is not gold in “AltMed Land” (Examiner article)

A home remedy for insomnia that appears to work (Examiner article)

DIET

 The key to avoiding many chronic diseases (Examiner article) 

KNOW YOURSELF & OTHERS BETTER

Alienation: Pervasive and insidious  (Examiner article) by Choctaw Doc

Extended Being (Examiner article) by Choctaw Doc

PREVENTION

 The key to avoiding many chronic diseases (Examiner article)

SEXUAL ISSUES

 Sex: We feed but can we tame the bulldog? (Examiner article)

Is an attachment style problem complicating or undermining your life? (Examiner article)

SPIRITUALITY

Did the Almighty send an emissary to the ancient Cahokians?

 

Rocking the Boat Blog Site Debuts

Experimental regimen targeting the ependyma slows disease progression in four patitents with ALS

 

Citation: Payne AG. ,’Experimental regimen targeting the ependyma slows disease progression in four patitents with ALS,’ Med Hypotheses (2009), doi:10.1016/j.mehy.2008.12.032 

Experimental regimen targeting the ependyma slows disease progression in four patients with amyotrophic lateral sclerosis

Dr. Anthony G. Payne*

 

E-mail: DrAGPayne@yahoo.com

 

SUMMARY

 

 In this paper the author proposes that at least some forms of sporadic ALS (amyotrophic lateral sclerosis) arise due to the effects of neurotoxic compounds synthesized by defective ependymal cells in the brain. These cells produce cerebrospinal fluid (CSF) that is laden with neurotoxic compounds that bring about motor neuron die-off. Evidence is garnered from various animal studies to demonstrate the toxicity of CSF taken from ALS patients and by virtue of the proposed mechanism (defective ependymal cells). In addition, a regimen created by the author is introduced; a regimen that has been used by four (4) sporadic ALS patients since 2005 resulting in what appears to be a slowing of disease progression. All four patients have significantly outlived best estimates of their survival tendered by their neurologists. 2009 Published by Elsevier Ltd.

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