Category Archives: Cancer

Making pancreatic cancer cells too acidic to survive

 

Pancreatic cancer blocked by disrupting cellular pH balance (Medical Express) by Sanford Burnham (Prebys Medical Discovery Institute) April 7, 2020

Scientists at Sanford Burnham Prebys have found a new way to kill pancreatic cancer cells by disrupting their pH equilibrium. The study, published in Cancer Discovery, reports how depleting an ion transport protein lowers the pH to a point that compromises pancreatic cancer cell growth.

“Our study suggests that interfering with cellular pH represents a new therapeutic avenue to treat pancreatic cancer, one of the deadliest cancers for which there is currently no effective treatment,” says Cosimo Commisso, Ph.D., an assistant professor in Sanford Burnham Prebys’ NCI-designated Cancer Center.’

“A new therapeutic avenue..”? Not exactly (Granted, the SBP scientists have their own unique way of lowering tumor cell pH). Check out this blog entry of mine: Exploiting a vulnerability in some forms of cancer: the Warburg Effect revisited

This particular  blog entry contains a link to a paper by “yours truly” from 2005: PREVENTING METASTASIS AND ACHIEVING ONCOLYSIS IN SOLID TUMORS BY INHIBITING SPECIFIC METALLOPROTEINASES AND MANIPULATING KEY METABOLIC PATHWAYS (Medical Hypotheses & Research, Vol. 2, No. 4, October 2005)

From the abstract section of my paper:

By artfully manipulating key metabolic anaerobic biochemical pathways, it should be possible to increase lactate and block its excretion, resulting in lethal reductions in intracellular pH. Compounds are advanced for accomplishing this as well as helping eradicate non-hypoxic regions of tumors, based on predecessor methods which results in long term remissions in per sons with a host of solid tumor malignancies. A number of measures are also introduced for inducing oncostasis and preventing metastasis.

This approach to effecting tumor cell die-off was dubbed by me “The Metabolic Oncolytic Regimen” and was first bandied about by me in 1989 (My original paper on this was posted online in 1989 followed by a revised spin in 2011).  

Its use by various oncologists in the US and abroad has put many patients with advanced and sometimes end stage metastatic cancer into partial and even full remission

This body of work attracted the attention of various staffers at the Office of Alternative Medicine (later reborn as the NCCAM) including NIH post-doc toxicologist Li-Chuan Chin which resulted in my being funded by the NIH to attend the historic Practice Outcomes Monitoring and Evaluation System (POMES) cancer conference held in Bethesda (in 1996). A few years later the faculty senate and president of a integrative medical school in Sri Lanka (Open International University of CAM) recognized the promise of the MOR by bestowing an honorary MD degree and 2 medals in science on me.

The revised Metabolic Oncolytic Regimen (MOR) is sometimes prescribed by MDs abroad who are also utilizing another of my brainchildren: Donor granulocyte therapy for advanced cancer (NCIM)

© April 2020 by Dr. Anthony G. Payne. All rights reserved.

Link to NCIM’s free e-guide to their experimental healing program

https://ncimexico.files.wordpress.com/2019/07/nova-cells-e-book-2019-edition.pdf

Exploiting a vulnerability in some forms of cancer: the Warburg Effect revisited

https://www.nature.com/articles/s42255-020-0172-2

 

This paper builds on work done in the 1980s by moi (Dr. Anthony G. Payne) which capitalized on the Warburg Effect in some forms of cancer.

 

https://biotheorist.files.wordpress.com/2020/02/manipulating-metalloproteinases-to-achieve-oncolysis-med-hyp-and-res.pdf

 

EXCERPT FROM MY FELLOWSHIP APPLICATION TO THE AMERICAN ACADEMY IN BERLIN (Submitted during the fall of 2019 for the 2020 award year):

In looking through the many completed Fellowship projects by American Academy of Berlin alumni as well as their biographical profiles, I quickly realized that both my proposal focus and background differs significantly from theirs. To quote myself, “I am the unconventional conventioneer”.

In keeping with my being a seeker of viable alternatives, the research I propose doing concerns maverick souls who exploited a metabolic defect that characterizes about 80% of the over 200 forms of cancer by throwing a monkey wrench in their inner  cellular works which culminated in tumor die-off in many of their patients. This defect, known as “the Warburg effect”, requires a little mental time travel:

Around 1923 German biochemist Otto Warburg, PhD, MD discovered that cancer cells use a lot of glucose and little or no oxygen to thrive (A process known as glycolysis). This didn’t make sense to Dr. Warburg as oxygen-fueled metabolic processes (oxidative phosphorylation) in cells were more efficient at generating energy for things like cell growth and proliferation, but repeated experiments by him showed that cancer cells generate lactic acid as a metabolic fuel via glycolysis and use this to help fuel growth, insure their survival, to multiply and to spread. Warburg concluded that it is a major player in cancer development and dubbed it “the Warburg effect”.

Dr. Warburg, who had joined the Kaiser Wilhelm  Institute (Berlin) in 1914 and eventually became head  of  its Cell Physiology Research Laboratory, won the Nobel Prize in Physiology in 1931 for discovering the role of specific enzymes involved in oxygen transfer in cells.

In January 1933 Adolf Hitler was appointed chancellor of Germany and, upon the death of Wiemar Republic President Paul Von Hindenburg in August 1934, combined the offices of chancellor and President into that of Fuehrer. In September 1935 the racist and antisemitic Nuremberg Laws were enacted by the Reichstag during the annual NSDAP (Nazi party) party rally in Nuremberg . Dr. Warburg, who was descended on his father’s side from Orthodox Jewish grandparents, could have easily been deported under German law but was not only left unmolested throughout the 12 year Reich but appears to have enjoyed the protective influence of men in industry who held high rank in the SS as well as Reichsmarshall Herman Goering (who had Dr. Warburg reclassified as 25% Jewish simply because “I decide who is a Jew”). Some historians have linked Hitler’s fear of developing cancer (which took the life of his mother) as well as a similar oncophobia in his Minister of Propaganda & Public Enlightenment, Dr. Paul Joseph Goebbels, to Dr. Warburg’s escaping deportation or worse (Some of Warburg’s relatives did not fare as well including one cousin and her mother who died in Sobibor and another cousin who died in Auschwitz).

Dr. Warburg outlived the Third Reich by almost a quarter century and during his lifetime published over 500 papers and five books. While he insisted the Warburg effect was the point of origin for cancer, the discovery of the molecular structure of DNA by James Watson and Francis Crick in 1953 put genes in the limelight and soon labs and research centers were linking deleterious mutations in specific genes to a wide range of inherited and acquired diseases and medical conditions including many forms of cancer. The Warburg effect was not just eclipsed by this focus on genes but actually was rarely mentioned in textbooks outside of a footnote or as a historical oddity.

Warburg died in 1970 having never proved that his “Warburg effect” triggered cancer. Evidence such as it was during this period of time suggested the Warburg effect was the result and not cause of roughly 80% of all cancer. But for some researchers and even a handful of medical mavericks and “fringe practitioners”, it was a vulnerability or Achilles Heel that could in theory be exploited to induce tumor cell die off.

One of these researchers was a NASA scientist, Clarence Cone, Jr., Ph.D., who filed for and received US patents [#s 4,724,230 (1988), 4,724,234 (1988), and 4,935,450 (1990)] on a method he pioneered which involves manipulating various metabolic and biochemical pathways in solid tumors such that they churn out prodigious quantities of lactate (lactic acid). This is achieved using a specific dietary regimen plus various synthetic and natural drugs. In addition, lactate export from tumors is blocked by he plant bioflavonoid quercitin which results in a lethal drop in intratumor pH (In short, they become too acidic to survive).

Dr. Cone included case histories of patients with various kinds of cancer who’d achieved partial and complete remission on his method in his patent applications. 

In 1989 I came across Dr. Cone’s body of work and immediately spotted a shortcoming: namely that it is hypoxic (low oxygen containing) clusters within certain solid tumors – and not the entire tumor – which synthesizes and exports lactic acid. Dr. Cone’s therapy is thus effective in helping eradicate hypoxic intratumor cell communities but did not generally produce die-off in the non-hypoxic regions of solid tumors.

My insights into how to improve Dr. Cone’s method gave birth to what I dubbed “The Metabolic Oncolytic Regimen” (MOR) which was published online by a website devoted to freely sharing ideas and papers from the realm of biomedical theory.

The MOR was subsequently employed by a handful of oncologists in the US and abroad resulting in numerous cases of partial and total remission in patients with solid tumors, most classified as advanced metastatic cases and some end-stage.

By 1995 my regimen had attracted the attention of scientists at the Office of Alternative Medicine (later reborn as the National Center for Complementary & Alternative Medicine and then the National Center for Complementary and Integrative Health) which resulted in my being funded to attend the historic Practice Outcomes Monitoring and Evaluation System (POMES) cancer conference in 1996, which I did. During the same year the President and Faculty Senate of the Open International University of Complementary & Alternative Medicines, a small integrative medical school in Sri Lanka, awarded me an honorary MD degree and 2 gold medals in science in recognition of the promise of the MOR in metabolic oncology.

This flurry of recognition proved short-lived, however. With the revival of interest by mainstream scientists and doctors in the Warburg effect following the publication of various laboratory studies that showed it could be exploited to eradicate certain tumor cell types, my MOR was quickly eclipsed and largely forgotten.

What I propose to do is document the pioneering metabolic oncology work of “unsung heroes” like Dr. Cone and bring this to light in the form of a book.

All blog entries: Categorized with links

https://biotheorist.files.wordpress.com/2018/07/for-seekers-other-heretics-blog-entries-menu.pdf

SEEKERS & OTHER HERETICS MENU - CATEGORIZED WITH LINKS

 

Video Quickie

Got 2 minutes to spare? Then sit back and enjoy a mix of fact, fantasy & tongue-n-cheek from “yours truly” (Dr. Anthony G. Payne)

 

Looking for treatment options for ALS, heart disease, cancer or eczema?

The Wizard of  MusumenPUBLISHED AS: Stepping out from behind the curtain

Many know me as “Anthony the writer”. Many doctors and clinics and labs know me as “Anthony the theorist”.  Actually a more apt moniker might be “Anthony the behind the scenes guy” as so much of my work is on behalf of companies and individual docs who pay to get my ideas and handiwork and affix their name to it without any mention of my authorship.  All this ghostwriting, ghost-editing and ghost-theorizing has helped carve out a niche for me as, well,…a living, breathing ghost (The working world’s invisible man).

However, some of the ventures and projects I am involved with can now be divulged albeit sans key details that could be ripped off and exploited by corporate competition aka money grubbing predators and scavengers.

Amyotrophic Lateral Sclerosis (ALS): Like cancer ALS is a hellacious nut to crack on all kinds of levels. However, evidence has emerged that suggests the disease is influence by aberrant proteins called prions and disease progress reflects the spread of these prions in the central nervous system (CNS). As part of my consultancy work I crafted an experimental combination drug and nondrug anti-prion regimen which was entrusted to MDs abroad (which they then approved and began using). This plus other novel forms of intervention slowed progression to a crawl in many treated ALS patients and has so far spared all of those treated from compromised respiratory functioning.  Of the handful who have died all of them simply went to sleep one night and didn’t wake up (“A good death” in many people’s book).

Atherosclerosis (Arterial blockage): The challenge of reversing arterial blockage has intrigued and engaged me since the mid-1980s. In fact, back then I was working with a Tibetan herbal formula called PADMA 28 that had accumulated evidence (from lab studies and also  randomized clinical trials) that it significantly reduced players in the arterial plaque-building process. I was, in fact, so impressed by the science that I approached the company that had brought PADMA 28 into the USA from Switzerland (where it is Swiss FDA approved to treated intermittent claudication), Berkley Health Network (BHN – later sold and reborn as Pacific BioLogic, Inc.), and began sharing ideas concerning other applications and experimental uses. It didn’t take long before their principle technical people asked me to serve as a scientific advisor which I did. Later I did experiments in which I took a large group of guinea pigs and divided them into 2 groups: Both ate a high saturated & trans fat rich diet geared to produce artery clogging diet which resulted in significant arterial blockage. However, one also was given PADMA 28 in their chow which eventually reversed their blockage. It did this, I think, because it dropped serum lipids and triglycerides so low that their bodies began mobilizing fats and such from their arterial plague. It also countered arterial and systemic inflammation which is a player in the plaque-building process.

In the years since I have added dietary and other measures to the PADMA 28 (now marketed as PADMA BASIC®) to increase plague reversal. Since I am not a physician and cannot diagnose or prescribe treatments, I have entrusted my ever-evolving ideas & resulting regimens to licensed MDs and DOs for their discretionary use. What has emerged is simply this: Many cases have accrued in which people with significant arterial blockage have demonstrated reversal to the point whereby angina and other symptoms ceased.

Note bene: I have no commercial interest in PADMA in any of its incarnations nor in any firm or such that markets or sells it.

https://biotheorist.files.wordpress.com/2017/08/padma-28-2017.pdf

Cancer especially advanced metastatic malignancy: Back in 1999 Wake Forest University researcher Zheng Cui, MD, PhD showed that there are super cancer-fighting immune cells called granulocytes in young animals that could obliterate cancer in old ones (mice). Borrowing a page from Dr. Cui’s animal work I created a regimen in which I proposed that pooled granulocytes isolated from the blood of young folks would be given daily to advanced cancer patients over a 10 to 14 day period (But given only to those who have exhausted conventional cancer fighting treatments and whose cancer is spreading and is predicted to end their lives in short order).

This approach was entrusted to a group of Mexican hematologists including one of the leading ones in all of Mexico and was approved for experimental clinical use (with the number of granulocytes and the frequency of their infusions to follow a strict protocol I worked out). The types of cancer subsequently treated included prostate, breast, lung, stomach and colorectal.

There is a <1% risk of a graft v. host reaction even months after a treatment cycle is concluded which all the patients doing it were informed of as part of informed consent.

To-date all advanced, end stage cancer patients treated have responded favorably with no graft v. host reactions occurring at all. Half of those treated experienced partial remission and half, full remission. Some have been technically cancer free for many, many years now.

Eczema: Back in the early 1990s J.I. Harper, MD at the Hospital for Sick Children in London, England put an ancient Chinese herbal eczema tea to the test in a double-blind placebo-controlled clinical involving children with eczema. The tea produced a tremendous diminution in itching, pustules, and scales, for example, while the children who sipped the placebo tea (the control group) did not significantly improve.

The herbs in the eczema tea were published but not the amounts of each. I decided to figure out this out carry out my own line of research. I recruited a large number of eczema patients – children, adolescents, and adults – mixed together the botanicals in varying proportions, and then gave out various versions. (Unlike the London study, however, I opted to use an encapsulated form as opposed to a foul-tasting tea).

It took over two years working at it part-time to arrive at the most effective combination for managing eczema, but effective it is! (My results paralleled those seen in the London-based clinical trials). And it’s not effective for eczema, but for other conditions in which certain species of free radicals and highly inflammatory substances called leukotrienes and prostaglandins play a role. The conditions which have shown a significant response to the eczema formula include asthma, emphysema, psoriasis, certain rheumatic conditions, and numerous neurological maladies.

I turned over the Eczema or E-Tea formula to a company I was consulting for at the time, Prestige Chinese Teas, in 1993. I’d known and collaborated with PCT founder and President Sunny Wong since 1986 and knew he’d so all he could to get E-Tea into the hands of medical consumers at a cost they could afford, which he did. I did not ask for and ever received any proceeds from the sale of E-Tea (as I did not want to add to its cost by doing so) and ceased to be paid as a consultant for PCT in 1999 when I left the USA to teach in Japan. As I anticipated, PCT has continued to make E-Tea available at a cost that is kind to consumer purse strings: http://www.teastohealth.com/skin.html

Sunny and his people have received many, many letters and statements from eczema patients, nurses and dermatologists down through the years attesting to E-Tea’s efficacy.

https://biotheorist.files.wordpress.com/2017/08/chinese-eczema-tea-version-2017.pdf

There are many more vexing medical challenges I have tackled down through the years (as a theorist) and a whole litany of them which has been placed on my plate by doctors, companies and even sufferers seeking answers that I am currently working on. And while I “live and move and have my being” for the most part in the Shadowlands you may come across my solutions down the line — albeit you likely will not know I am behind it.

© 2014 by Anthony G. Payne. All rights reserved.

Eradicating cancer: Metabolic monkey wrenching including use of autophagy inhibitors

On 9-6-2012 ScienceDaily ran this article:  http://www.sciencedaily.com/releases/2012/09/120906074249.htmAcidic Microenvironments in Tumors Aid Tumor Cell Survival, Researchers Find

Here is a link to the full paper(Cancer Res 2012;72:3938-3947. Published Online First June 19, 2012) for those interested in perusing this: http://cancerres.aacrjournals.org/content/72/16/3938.full.pdf+html  – Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

Interestingly, my Metabolic Oncolytic Regimen (original body of theory – 1990 — various permutations since) is based on lowering pH in hypoxic regions of solid tumors to lethal levels: http://www.healingcare4u.org/The%20Metabolic%20Oncolytic%20Regimen%20(Revised%202011).pdf

However, as the paper in the Cancer Research Journal (link above) signals, tumor cells in acidic regions adapt and survive by chronically activating autophagy pathways. Thankfully though, this can be circumvented by use of autophagy inhibitors:   

http://www.landesbioscience.com/journals/autophagy/BenSahraAUTO6-5.pdfThe combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

http://www.jbc.org/content/281/46/34870.full.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557039/

http://www.sigmaaldrich.com/life-science/cell-biology/cell-biology-products.html?TablePage=104899425List of Autophagy inhibitors (Sigma Chemical) including N-acetyl-cysteine

http://www.tocris.com/pharmacologicalBrowser.php?ItemId=296970&Type=Inhibitors Autophagy Inhibitors – Tocris Bioscience

Hydroxychloroquine and chloroquine are autophagy inhibitors.

http://www.nature.com/nbt/journal/v30/n7/fig_tab/nbt.2285_T2.htmlTable 2: Autophagy inducers and inhibitors for cancer treatment

This line of work & reasoning suggests that a marriage of the MOR (or a similar “metabolic anti-tumor monkey wrenching” approach) with one or more autophagy inhibitors should deliver a death blow to at least some solid tumors. 

 

 

 

Through the CAM looking Glass

Looking glass worldshttps://biotheorist.files.wordpress.com/2018/07/natural-medicine-a-cautionary-look.pdf

Study reveals that masturbation reduces odds of developing prostate cancer

There have been a number of studies that suggest that regular masturbation by men, especially during their youth to perhaps age 50, flushes carcinogens that tend to accumulate in the prostate from the gland and by so doing help prevent initiation of cancer in this gland. One recent one was carried out by the Council of Victoria which revealed that men who masturbate to ejaculation more than five times per week were one-third less likely to develop prostate cancer.

If this correlation is true, it logically follows that the greater the degree of prostate “emptying” the more likely a man is to purge his prostate of cancer-causing compounds and thus the lower his risk of developing carcinoma of the prostate. There are a number of ways to (ahem) pull this off:

(1) Prostate massage: This commercial website appears to provide some really sound advice in this regard. Note that I have no financial or other interest in this website of any firm it links to or promotes.

(2) Masturbate while using the a prostate electrostimulation device. These provide users with what amounts to a gentle though powerful pulsating “electric massage” of the prostate which is highly stimulating and pleasurable. Many men report having more copious ejaculations when they climax while using this type of gadget (Which is the goal when it comes to draining the prostate of fluids that might harbor carcinogenic substances). It is also reputed to jump-start the erection machinery in the male body which leads to firmer, stronger erections.

(3) Use the Aneros prostate massager or something similar during masturbatory sessions .

Also check out: OSTEOPOROSIS IN WOMEN: SEMINAL FLUID COMPOUNDS ABSORBED THROUGH MUCOSAL TISSUES HELP PROTECT AGAINST & REMEDIATE BONE LOSS   (Idea/hypothesis) by Dr. Payne.

Disclaimer: Dr. Payne has no financial or other commercial interest in any device or firm marketing same mentioned in this article. 

The information contained in this article is provided for informational purposes only and should not be construed as medical advice or instruction. Readers are advised to consult a licensed health care professional concerning all matters related to their health and well being.

© 2011 by Dr. Anthony G. Payne. All rights reserved.

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