Anthony G. Payne Dr. Dennis is a professor of bioengineering at the University of North Carolina (UNC) and worked for NASA as a research scientist. I actually have been evaluating the efficacy of his unique M1 PEMF technology to remediate pain & stimulate cartilage and bone regeneration in volunteers. We seem to share a passion for equipping people with the know-how to help themselves. Check out this this <5 minute video in which Dr. Dennis explains how to make-a ventilator-at-home.
Category Archives: NUTRITION & DIET
When cancer struck family – and what turned things around
My paternal great-great-grandfather, Richard Payne farmed a large spread outside Tupelo, Mississippi in the 1850s into the 1860s. After a major battle was fought there between the army of the CSA and Gen. Grant’s US troops in mid-July 1864, my great-great-grandfather joined the Confederate Army and wound up serving in a Calvary regiment. Great-great-grandfather Payne was given the rank of corporal going in and proceeded to participate in some of the bloodiest battles that occurred in the final 9 months of the Civil War.
After the war, my great-great grandfather’s boys — which included my great grandfather William Wylie Payne (1862-1948) — moved to Texas. One, Dr. Franklin Payne was a veterinarian who died in a barn fire, sad to say, in some dinky doo town in east Texas. The other boys moved to North Texas where William Wylie bought and operated a farm in Floyd County (Near Floydada where my father was born in 1930). He had a number of sons including Reggie Vernon Payne (b. 1895 d. 1976), my grandfather, who married Nettie Alice Warren just before or right after WW1. They had 3 children — one of whom was my father, Walter W. Payne (1930-1992).
Read the rest of this entryCOVID-19: food compounds that inhibit a key enzyme in SARS-CoV-2 gene expression and replication
Link to the full paper: Frontiers | Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2 | Plant Science (frontiersin.org)
Although the study covered in the paper (link above) involved a combination of computer simulation & benchtop experiments, I know from decades of interaction with medical information & product consumers that some of you reading this will want to know “the bottom-line” — mainly so you can go out and buy the foods and/or food concentrates or extracts in question. OK then, here it is:
Most effective in inhibiting the SAR-Co-2 (Covid-19) Mpro enzyme activity were certain green tea compounds such as EGCG and extracts from two muscadine grape cultivars (grapes + skin & seeds).
Cocoa and raw chocolate compounds were the “runners up”.
From the paper: “Conclusion, both docking simulation and in vitro assay showed that (–)-catechin-3-O-gallate (7), (–)-epicatechin-3-O-gallate (8), (–)-gallocatechin-3-O-gallate (9), and (–)-epigallocatechin-3-O-gallate (10), procyanidin B1 (11) and B2 (12) inhibited the Mpro activity of SARS-Cov-2. Moreover, these compound-rich extracts of green tea, muscadine grape, cacao, and dark chocolate also inhibited the Mpro activity.”
Green tea, muscadine, cacao and raw chocolate extracts, concentrates and such are sold all across cyber-land. Here are a few for you to check out (Note that I have no commercial, financial or other vested interest in these products):
Green tea extract capsules:
Vitacost Green Tea Extract – Standardized — 500 mg – 100 Capsules – Vitacost
Zhou Green Tea Extract 500 mg 120 Veg Caps – Swanson Health Products (swansonvitamins.com)
Epigallocatechin gallate (ECGC) capsules:
NOW Foods EGCg Green Tea Extract 400 mg 180 Veg Caps – Swanson Health Products (swansonvitamins.com)
Muscadine grape products
Vitacost Muscadine Grape Seed — 500 mg – 120 Capsules – Vitacost
VineLife Muscadine Grape Seed & Skin 650mg – 60 Veggie … (searchwellness.com)
Cacao & dark chocolate
VitaDigest.com Offer – Earth Circle Organics, Organic Raw 70% Dark Chocolate, 8.8 oz (250 g)
Growing your own food
Beginner Gardening Tips for a Successful Garden – Grow Your Own Food! (19m09s video by Rob Greenfield, posted 6-15-2020)
https://www.communitygarden.org/
If you want to want (or need) to begin growing your own vegetables and fruits, the video above and the 2 organizations I provided links to should get you started.
And, for those who want helpful hints on how to do container gardening right, check out https://www.treehugger.com/secret-container-vegetable-gardening-4863889
Program note: I spent my summer vacations and more lending a hand to my Choctaw maternal grandfather who owned & farmed 300 acres north of the rustic Panhandle town of Plainview, Texas. This equipped me with some insights on how to grow vegetables & various kinds of fruit and keep weeds and insects at bay.
I’ve also raised vegetables and dwarf fruit bushes in various types of containers outdoors down through the years (I am doing this right now on the patio of my Japanese wife and I’s abode in SoCal).
And done stints in Ag labs and greenhouses devoted to growing various culinary mushrooms and more.
I say all this to indicate my familiarity with the challenges that face farmers and home gardeners. I will periodically post helpful hints gleamed from my years of work and experimentation.
America is obviously in dire economic shape right now and backyard and community gardening projects will help growers reduce their food bills and also (hopefully) give them surplus to donate to local food banks.
Personally I am in favor of folks pooling their resources and buying land, setting up fire, earthquake & storm resistant homes (off the grid or nearly so), making use of water & land conserving equipment (high tech & intermediate tech) and devoting acreage to growing many different types of vegetables & fruits. Some who go this route might find merit in setting up a nonprofit co-op or such.
Recently I became a VP/CSO with a nonprofit religious university (More on this later on). This school has a school of ecology with many professors who have worked in agricultural projects and communes abroad. You can bet your bottom dollar I will be tapping these highly educated and experienced professionals for tips, insights and caveats for novice “patio farmers” as well as those who have their sights on buying a farmette or such and living off the land.
Readers can contact me at nativescienceguy at gmail.com.
Making pancreatic cancer cells too acidic to survive
Pancreatic cancer blocked by disrupting cellular pH balance (Medical Express) by Sanford Burnham (Prebys Medical Discovery Institute) April 7, 2020
Scientists at Sanford Burnham Prebys have found a new way to kill pancreatic cancer cells by disrupting their pH equilibrium. The study, published in Cancer Discovery, reports how depleting an ion transport protein lowers the pH to a point that compromises pancreatic cancer cell growth.
“Our study suggests that interfering with cellular pH represents a new therapeutic avenue to treat pancreatic cancer, one of the deadliest cancers for which there is currently no effective treatment,” says Cosimo Commisso, Ph.D., an assistant professor in Sanford Burnham Prebys’ NCI-designated Cancer Center.’
“A new therapeutic avenue..”? Not exactly (Granted, the SBP scientists have their own unique way of lowering tumor cell pH). Check out this blog entry of mine: Exploiting a vulnerability in some forms of cancer: the Warburg Effect revisited
This particular blog entry contains a link to a paper by “yours truly” from 2005: PREVENTING METASTASIS AND ACHIEVING ONCOLYSIS IN SOLID TUMORS BY INHIBITING SPECIFIC METALLOPROTEINASES AND MANIPULATING KEY METABOLIC PATHWAYS (Medical Hypotheses & Research, Vol. 2, No. 4, October 2005)
From the abstract section of my paper:
By artfully manipulating key metabolic anaerobic biochemical pathways, it should be possible to increase lactate and block its excretion, resulting in lethal reductions in intracellular pH. Compounds are advanced for accomplishing this as well as helping eradicate non-hypoxic regions of tumors, based on predecessor methods which results in long term remissions in per sons with a host of solid tumor malignancies. A number of measures are also introduced for inducing oncostasis and preventing metastasis.
This approach to effecting tumor cell die-off was dubbed by me “The Metabolic Oncolytic Regimen” and was first bandied about by me in 1989 (My original paper on this was posted online in 1989 followed by a revised spin in 2011).
Its use by various oncologists in the US and abroad has put many patients with advanced and sometimes end stage metastatic cancer into partial and even full remission
This body of work attracted the attention of various staffers at the Office of Alternative Medicine (later reborn as the NCCAM) including NIH post-doc toxicologist Li-Chuan Chin which resulted in my being funded by the NIH to attend the historic Practice Outcomes Monitoring and Evaluation System (POMES) cancer conference held in Bethesda (in 1996). A few years later the faculty senate and president of a integrative medical school in Sri Lanka (Open International University of CAM) recognized the promise of the MOR by bestowing an honorary MD degree and 2 medals in science on me.
The revised Metabolic Oncolytic Regimen (MOR) is sometimes prescribed by MDs abroad who are also utilizing another of my brainchildren: Donor granulocyte therapy for advanced cancer (NCIM)
© April 2020 by Dr. Anthony G. Payne. All rights reserved.
NYC hospitals using high dose IV vitamin C on COVID-19 patients
New York hospitals treating coronavirus patients with vitamin C
By Lorena Mongelli and Bruce Golding
March 24, 2020 | 5:04pm |
EXCERPTS FROM THIS ARTICLE
Dr. Andrew G. Weber, a pulmonologist and critical-care specialist affiliated with two Northwell Health facilities on Long Island, said his intensive-care patients with the coronavirus immediately receive 1,500 milligrams of intravenous vitamin C.
Identical amounts of the powerful antioxidant are then readministered three or four times a day, he said.
A spokesman for Northwell — which operates 23 hospitals, including Lenox Hill Hospital on Manhattan’s Upper East Side — said vitamin C was being “widely used” as a coronavirus treatment throughout the system, but noted that medication protocols varied from patient to patient.
“As the clinician decides,” spokesman Jason Molinet said.
The vitamin C is administered in addition to such medicines as the anti-malaria drug hydroxychloroquine, the antibiotic azithromycin, various biologics and blood thinners, Weber said.
Weber, 34, said vitamin C levels in coronavirus patients drop dramatically when they suffer sepsis, an inflammatory response that occurs when their bodies overreact to the infection.
“It makes all the sense in the world to try and maintain this level of vitamin C,” he said.
A clinical trial on the effectiveness of intravenous vitamin C on coronavirus patients began Feb. 14 at Zhongnan Hospital in Wuhan, China, the epicenter of the pandemic
https://nypost.com/2020/03/24/new-york-hospitals-treating-coronavirus-patients-with-vitamin-c/
COVID-19 turnarounds in 50 hospitalized patients (moderate to severe) – no deaths — results reported during an international video medical conference
Antivirus coated masks preventing infection with COVID-19
Antivirus nasal spray you can make at home (Git-R-Done)
FIGHTING BACK AGAINST COVID-19 (Updated 12-11-2020) fighting-back-against-covid-19-updated-on-12-11-2020-1.pdf (wordpress.com)
FIGHTING COVID-19: immune support foods + 2 products
Far-UV technology kills COVID-19 & bacteria & fungi in offices, rooms, etc. (Far-UV doesn’t penetrate skin or eyes)
COVID-19: Lots of easy to access posts on my FACEBOOK page
COVID-19: Don’t let fear get the best of you
Thought-provoking documentary on where the COVID-19 pandemic may be taking us
FIGHTING COVID-19: immune support foods + 2 products
NOTA BENE: I have no financial or other vested interested in any products or devices mentioned in or linked to in this article.
COVID-19: Lots of easy to access posts on my FACEBOOK page
I post many news articles & such on COVID-19 (and much more) along with my comments in many instances on my Facebook page at https://www.facebook.com/DrAGPayne.choctawdoc
My posts are almost always accessible by the public (This way you do not need to become a “Facebook Friend” of mine to access and read them).
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MAKE A VENTILATOR AT HOME
https://www.youtube.com/watch…
youtube.com
Anthony G. Payne PS I sincerely hope you NEVER have to make & use this homemade ventilator on a COVID-19 stricken spouse, relative, friend, or such!
Antivirus nasal spray you can make at home (Git-R-Done)
The fish tank cleaner contains the same active ingredient as the drug, but in a different form that can poison people.
washingtonpost.com
The fish tank cleaner contains the same active ingredient as the drug, but in a different form that can poison people.
Anthony G. Payne The toxicity of even the right drug – chloroquine — as well as hydroxychloroquinine — and the lack of substantive evidence that they actually produce benefits outweighing the risks — are prompting many scientists and docs to hit the pause button on them. However, back in the mid 1980s while dealing with a handful of AIDs sufferers (Dallas) I had them try a specific compound that was nontoxic — showed activity against certain parasites and viruses — and which actually had an positive impact of their condition. This whole chloroquinine discussion got to me to reflecting on this. Now I am arranging to obtain my old chemical friend and combine it with the other nontoxic antiviral compounds to see if it will make a dent in COVID-19 in the lab (I do not work with the actual virus but have a pipeline to researchers who are and who are seeking novel solutions to test against this insidious virus). Ever forward….
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Idiot pastor in Ohio holds Sunday service in his megachurch
In Warren County, Ohio, a state where the governor has issued a stay-at-home mandate to slow the spread of coronavirus, Solid Rock Church pastor Lawrence Bishop invited worshippers yesterday to his…
boingboing.net
In Warren County, Ohio, a state where the governor has issued a…
In Warren County, Ohio, a state where the governor has issued a stay-at-home mandate to slow the spread of coronavirus, Solid Rock Church pastor Lawrence Bishop invited worshippers yesterday to his…
Anthony G. Payne I suspect the pastor of this megachurch has trouble distinguishing presumption from faith. It is an intellectual defect I’ve seen at work in many congregations down through the years, sometimes with tragic consequences.
Anthony G. Payne Thankfully it appears most megachurch leaders have already wised up……https://slate.com/…/its-a-big-deal-that-megachurches…
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slate.comIt’s a Big Deal That Megachurches Are Canceling Live ServicesIt’s a Big Deal That Megachurches Are Canceling Live Services
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Exploiting a vulnerability in some forms of cancer: the Warburg Effect revisited
https://www.nature.com/articles/s42255-020-0172-2
This paper builds on work done in the 1980s by moi (Dr. Anthony G. Payne) which capitalized on the Warburg Effect in some forms of cancer.
EXCERPT FROM MY FELLOWSHIP APPLICATION TO THE AMERICAN ACADEMY IN BERLIN (Submitted during the fall of 2019 for the 2020 award year):
In looking through the many completed Fellowship projects by American Academy of Berlin alumni as well as their biographical profiles, I quickly realized that both my proposal focus and background differs significantly from theirs. To quote myself, “I am the unconventional conventioneer”.
In keeping with my being a seeker of viable alternatives, the research I propose doing concerns maverick souls who exploited a metabolic defect that characterizes about 80% of the over 200 forms of cancer by throwing a monkey wrench in their inner cellular works which culminated in tumor die-off in many of their patients. This defect, known as “the Warburg effect”, requires a little mental time travel:
Around 1923 German biochemist Otto Warburg, PhD, MD discovered that cancer cells use a lot of glucose and little or no oxygen to thrive (A process known as glycolysis). This didn’t make sense to Dr. Warburg as oxygen-fueled metabolic processes (oxidative phosphorylation) in cells were more efficient at generating energy for things like cell growth and proliferation, but repeated experiments by him showed that cancer cells generate lactic acid as a metabolic fuel via glycolysis and use this to help fuel growth, insure their survival, to multiply and to spread. Warburg concluded that it is a major player in cancer development and dubbed it “the Warburg effect”.
Dr. Warburg, who had joined the Kaiser Wilhelm Institute (Berlin) in 1914 and eventually became head of its Cell Physiology Research Laboratory, won the Nobel Prize in Physiology in 1931 for discovering the role of specific enzymes involved in oxygen transfer in cells.
In January 1933 Adolf Hitler was appointed chancellor of Germany and, upon the death of Wiemar Republic President Paul Von Hindenburg in August 1934, combined the offices of chancellor and President into that of Fuehrer. In September 1935 the racist and antisemitic Nuremberg Laws were enacted by the Reichstag during the annual NSDAP (Nazi party) party rally in Nuremberg . Dr. Warburg, who was descended on his father’s side from Orthodox Jewish grandparents, could have easily been deported under German law but was not only left unmolested throughout the 12 year Reich but appears to have enjoyed the protective influence of men in industry who held high rank in the SS as well as Reichsmarshall Herman Goering (who had Dr. Warburg reclassified as 25% Jewish simply because “I decide who is a Jew”). Some historians have linked Hitler’s fear of developing cancer (which took the life of his mother) as well as a similar oncophobia in his Minister of Propaganda & Public Enlightenment, Dr. Paul Joseph Goebbels, to Dr. Warburg’s escaping deportation or worse (Some of Warburg’s relatives did not fare as well including one cousin and her mother who died in Sobibor and another cousin who died in Auschwitz).
Dr. Warburg outlived the Third Reich by almost a quarter century and during his lifetime published over 500 papers and five books. While he insisted the Warburg effect was the point of origin for cancer, the discovery of the molecular structure of DNA by James Watson and Francis Crick in 1953 put genes in the limelight and soon labs and research centers were linking deleterious mutations in specific genes to a wide range of inherited and acquired diseases and medical conditions including many forms of cancer. The Warburg effect was not just eclipsed by this focus on genes but actually was rarely mentioned in textbooks outside of a footnote or as a historical oddity.
Warburg died in 1970 having never proved that his “Warburg effect” triggered cancer. Evidence such as it was during this period of time suggested the Warburg effect was the result and not cause of roughly 80% of all cancer. But for some researchers and even a handful of medical mavericks and “fringe practitioners”, it was a vulnerability or Achilles Heel that could in theory be exploited to induce tumor cell die off.
One of these researchers was a NASA scientist, Clarence Cone, Jr., Ph.D., who filed for and received US patents [#s 4,724,230 (1988), 4,724,234 (1988), and 4,935,450 (1990)] on a method he pioneered which involves manipulating various metabolic and biochemical pathways in solid tumors such that they churn out prodigious quantities of lactate (lactic acid). This is achieved using a specific dietary regimen plus various synthetic and natural drugs. In addition, lactate export from tumors is blocked by he plant bioflavonoid quercitin which results in a lethal drop in intratumor pH (In short, they become too acidic to survive).
Dr. Cone included case histories of patients with various kinds of cancer who’d achieved partial and complete remission on his method in his patent applications.
In 1989 I came across Dr. Cone’s body of work and immediately spotted a shortcoming: namely that it is hypoxic (low oxygen containing) clusters within certain solid tumors – and not the entire tumor – which synthesizes and exports lactic acid. Dr. Cone’s therapy is thus effective in helping eradicate hypoxic intratumor cell communities but did not generally produce die-off in the non-hypoxic regions of solid tumors.
My insights into how to improve Dr. Cone’s method gave birth to what I dubbed “The Metabolic Oncolytic Regimen” (MOR) which was published online by a website devoted to freely sharing ideas and papers from the realm of biomedical theory.
The MOR was subsequently employed by a handful of oncologists in the US and abroad resulting in numerous cases of partial and total remission in patients with solid tumors, most classified as advanced metastatic cases and some end-stage.
By 1995 my regimen had attracted the attention of scientists at the Office of Alternative Medicine (later reborn as the National Center for Complementary & Alternative Medicine and then the National Center for Complementary and Integrative Health) which resulted in my being funded to attend the historic Practice Outcomes Monitoring and Evaluation System (POMES) cancer conference in 1996, which I did. During the same year the President and Faculty Senate of the Open International University of Complementary & Alternative Medicines, a small integrative medical school in Sri Lanka, awarded me an honorary MD degree and 2 gold medals in science in recognition of the promise of the MOR in metabolic oncology.
This flurry of recognition proved short-lived, however. With the revival of interest by mainstream scientists and doctors in the Warburg effect following the publication of various laboratory studies that showed it could be exploited to eradicate certain tumor cell types, my MOR was quickly eclipsed and largely forgotten.
What I propose to do is document the pioneering metabolic oncology work of “unsung heroes” like Dr. Cone and bring this to light in the form of a book.
How much vitamin C should one take?
Recently I was asked (on Facebook) how much vitamin C I take, which begs the question: What is the optimal intake of vitamin C for most people?
This is from my Facebook reply:
In order to answer this, I need to jump in the Way Back machine:
Back when I was studying for my doctorate in nutritional medicine (mid 1980s) there was a spirited debate going on among researchers, doctors, nutritionists and others concerning how much vitamin C a human being needed and could handle. Because I came into the realm of human nutrition with a background in biological anthropology (BS, MA) – training I actually undertook purposely not only because I dearly love bio anthro but also because I consider the insights and tools it provides foundational to understanding evolutionary players in human health & disease (and by virtue of this helpful in setting the stage for medical or paramedical studies) – I looked at the quantities of vitamin C produced in mammals that have retained the capacity to do so (Humans and many other primates such as gorillas lost this ability long ago). What emerged is that most nonhuman primates synthesis 25 mg of vitamin C per kilogram of body weight. If one applies this figure to an average (70 kg) human, this comes out to 1750 mg total daily.
There are, of course, mitigating factors. We know 70-90% of the vitamin C people get from food and supplemental forms are absorbed. However, too much taken all at one time reduces absorption! (If you take 1 gram of vitamin C only 50% will be absorbed). However, people with certain chronic diseases appear to absorb and use more even at high intakes.
With all this said, conventional thinking indicates that any amount of vitamin C over 180 mg daily will exceed what the tissues throughout the body can handle (i.e., saturation is reached) and the excess will be processed by the kidneys and dumped in the urine.
After years of dealing with people with chronic diseases, I have come to believe they should be taking 1750 mg to as much as 4 grams of vitamin C in divided doses daily (as their bodies can handle so much more C and apparently need this to support innate disease fighting processes). For healthy young to middle-aged folks, 180 mgs in divided doses or in slow or time release form should be adequate to meet the body’s demands for vitamin C.
Now to your specific question: How much C do I take daily? 500 mg Metabolic C in divided doses (100 mg every 3 hours from morning until evening). I take more than the 180 mg I mentioned above because I am getting older (62) and believe additional C is a good preventative measure as chronic disease processes are often subtlety at work (in even the healthiest of us) with increasing age.
Some folks argue for mega dosing – to “bowel tolerance” – whether healthy or not – which I think is a bit reckless (Most do it to “prevent various diseases especially cancer”). Vitamin C works as an antioxidant at low doses but can promote the production of ROS (reactive oxygen species) molecules when serum levels are very high. These ROS molecules can damage cell membranes and cause other biophysiological problems. As I recall, Nobel prize winning chemist Dr. Linus Pauling ingested mega doses of C daily for years on end. He lived to be 93 but died of prostate cancer. Some have argued his disease was triggered by his mega dosing on C. Dr. Pauling contended his high dose C kept his cancer at bay for years. One thing is certain: Years before Pauling’s’ demise, controlled studies were carried out to see if high dose C impacted various forms of cancer in animals and humans. The bottom line: It was ineffective. Advocates of high dose use of C rejected these studies for various reasons, while most of the scientific community accepted them as valid. The debate goes on to this day in various quarters
A parting word of advice: Do not “super mega dose” to prevent or treat disease. Those individuals reading this who have cancer and are considering using vitamin C to fight it should peruse https://www.cancer.gov/about-cancer/treatment/cam/patient/vitamin-c-pdq
And so it goes……as do I…….
Of PQQ, Nutcracker Man & Tiger Nuts (PQQ as radioprotective with heart & nervous system benefits)
Pyrroloquinoline quinone – Wikpedia
I have worked with a coenzyme called pyrroloquinoline quinone (PQQ) for quite a while now and think it is worth a “look see” by physicians and others for its preventative and therapeutic potential. Let’s dive into this now:
First, let’s “do the time warp, now”: During 1994-5 I worked in an Ag lab and large greenhouse complex outside Lincoln, Nebraska (Which was devoted to the testing of various nature-derived growth accelerants on culinary & medicinal mushrooms). One of the principle consulting researchers who rubbed elbows with me was Andy Anderson, PhD, who discovered a radioresistant bacterium back in 1956 while irradiating food at the Oregon Agricultural Experimental Station in Corvallis (As I recall from our chitchat, he was irradiating canned foods to see if this would reliably preserve them against spoilage). The bacterium was subsequently dubbed Deinococcus radiodurans and is indisputably the most radioresistant organism discovered to-date.
Reversing arterial blockage: Experimental regimen that worked for man facing amputation of his lower legs
Last year (2012) I was contacted by a gentleman who had severe blockage in his legs and had been told by his physician-surgeon that he would need to amputate his legs below the knee. Naturally this chap was horrified at the prospect of living his life out of a wheelchair and/or on crutches and was frantic to know if there is anything, however experimental, that might help him avoid the surgeon’s knife. Apparently he had done a Google search and come across some of my health-related hypotheses (I have since 1986, been paid by various docs & researchers to spin hypotheses and provide novel ideas they could then pursue – or not).
I could not, of course, prescribe anything whatsoever as I am not a physician and lack the qualifications to get into such matters. However, what I did do is hand off an experimental regimen I originally developed in the late 1980s and had updated recently, along with the stringent caveat that much of my own work and that which informed it involved animal models of arterial blockage and I was giving him this with the strict understanding he would share it with his primary care MD and do what he said or advised.
I heard nothing from this chap for about 8 months and then got a call. It seems he was able to get his MD to endorse my handwork which he had followed religiously. Long story short, the circulation in his legs had improved to the point that amputation was no longer on the proverbial table. Needless to say he and his wife of some 50+ years were overjoyed by his progress.
So here is what I shared with this guy – again, with the caveat it is experimental and unproved and should not be undertaken without the express consent & supervision of a duly licensed & practicing MD or DO.
TO READ THE REST OF MY ARTICLE GO TO https://biotheorist.files.wordpress.com/2018/07/reversing-pad-cad-experimental-regimen-write-up-august-2013.pdf
Is cooking the main culprit behind the arterial blockage seen in the Horus mummies study?
During March of this year (2013) a paper appeared in the journal The Lancet titled “Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations”. You may have seen something about this among the many news articles and blurbs posted across the Web on the heels of this paper’s publication. If not, check out Science Daily’s excellent lay level piece on it at http://www.sciencedaily.com/releases/2013/03/130311091537.htm
You can read the paper in its entirety at http://download.thelancet.com/flatcontentassets/pdfs/S014067361360598X.pdf I perused it right after it came out and would like to share my thoughts on a possible culprit behind the arterial blockage that bedeviled the ancient peoples represented in the Horus study and which has cast a long shadow over modern populations as well (The fabled “Iceman“ Ötzi showed evidence of atherosclerosis too albeit he had a genetic predisposition and evidence of a chronic infection, namely borreliosis or Lyme disease).
CLICK THIS LINK TO READ THE REST OF THIS ARTICLE
To slow aging => Reduce HIF-1 alpha (?)
Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction
“Animals that were designed to over-express HIF-1 did not get the benefit of lifespan extension even though their diets were restricted. Animals that under-expressed HIF-1 lived longer, even when they had a nutrient-rich diet. Furthermore, it was found that the lifespan extension resulting from dietary restriction required activity in signaling pathways in the endoplasmic reticulum, the part of the cell involved in processing and the proper folding of proteins. This finding supports the theory that aging stems from the effects of misfolded proteins and opens up a rich area of investigation to examine the mechanisms by which stress in the endoplasmic reticulum affects lifespan”
Carcinogenesis. 2009 Apr;30(4):636-44. Epub 2009 Jan 8. Links
Grape seed extract inhibits VEGF expression via reducing HIF-1alpha protein expression.
Department of Molecular Medicine, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA.
Grape seed extract (GSE) is a widely consumed dietary supplement that has antitumor activity. Here, we have investigated the inhibitory effect of GSE on the expression of vascular endothelial growth factor (VEGF) and the mechanism underlying this action. We found that GSE inhibited VEGF messenger RNA (mRNA) and protein expression in U251 human glioma cells and MDA-MB-231 human breast cancer cells. GSE inhibited transcriptional activation of the VEGF gene through reducing protein but not mRNA expression of hypoxia-inducible factor (HIF) 1alpha. The inhibitory effect of GSE on HIF-1alpha expression was mainly through inhibiting HIF-1alpha protein synthesis rather than promoting protein degradation. Consistent with this result, GSE-suppressed phosphorylation of several important components involved in HIF-1alpha protein synthesis, such as Akt, S6 kinase and S6 protein. Furthermore, in the MDA-MB-231 tumor, we found that GSE treatment inhibited the expression of VEGF and HIF-1alpha and the phosphorylation of S6 kinase without altering the subcellular localization of HIF-1alpha, correlating with reduced vessel density and tumor size. Depletion of polyphenol with polyvinylpyrrolidone abolished the inhibitory activity of GSE, suggesting a water-soluble fraction of polyphenol in GSE is responsible for the inhibitory activity. Taken together, our results indicate that GSE inhibits VEGF expression by reducing HIF-1alpha protein synthesis through blocking Akt activation. This finding provides new insight into the mechanisms of anticancer activity of GSE and reveals a novel molecular mechanism underlying the antiangiogenic action of GSE.
PMID: 19131542 [PubMed – indexed for MEDLINE]
PMCID: PMC2664452 [Available on 2010/04/01]
Biochem Biophys Res Commun. 2009 Apr 24;382(1):96-101. Epub 2009 Feb 28. Links
D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells.
Park JY, Park JW, Suh SI, Baek WK.
Chronic Disease Research Center, School of Medicine, Keimyung University, 194 Dongsan-Dong, Jung-Gu, Daegu 700-712, Republic of Korea.
D-glucosamine has been reported to inhibit proliferation of cancer cells in culture and in vivo. In this study we report a novel response to D-glucosamine involving the translation regulation of hypoxia inducible factor (HIF)-1alpha expression. D-glucosamine caused a decreased expression of HIF-1alpha under normoxic and hypoxic conditions without affecting HIF-1alpha mRNA expression in DU145 prostate cancer cells. D-glucosamine inhibited HIF-1alpha accumulation induced by proteasome inhibitor MG132 and prolyl hydroxylase inhibitor DMOG suggesting D-glucosamine reduces HIF-1alpha protein expression through proteasome-independent pathway. Metabolic labeling assays indicated that D-glucosamine inhibits translation of HIF-1alpha protein. In addition, D-glucosamine inhibited HIF-1alpha expression induced by serum stimulation in parallel with inhibition of p70S6K suggesting D-glucosamine inhibits growth factor-induced HIF-1alpha expression, at least in part, through p70S6K inhibition. Taken together, these results suggest that D-glucosamine inhibits HIF-1alpha expression through inhibiting protein translation and provide new insight into a potential mechanism of the anticancer properties of D-glucosamine.
PMID: 19254699
For Seekers & Other Heretics 